ZIKV - CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms

PLoS Neglected Tropical Diseases
Victor Satler PylroGabriel Rocha Fernandes


In early 2015, a ZIKA Virus (ZIKV) infection outbreak was recognized in northeast Brazil, where concerns over its possible links with infant microcephaly have been discussed. Providing a causal link between ZIKV infection and birth defects is still a challenge. MicroRNAs (miRNAs) are small noncoding RNAs (sncRNAs) that regulate post-transcriptional gene expression by translational repression, and play important roles in viral pathogenesis and brain development. The potential for flavivirus-mediated miRNA signalling dysfunction in brain-tissue development provides a compelling hypothesis to test the perceived link between ZIKV and microcephaly. Here, we applied in silico analyses to provide novel insights to understand how Congenital ZIKA Syndrome symptoms may be related to an imbalance in miRNAs function. Moreover, following World Health Organization (WHO) recommendations, we have assembled a database to help target investigations of the possible relationship between ZIKV symptoms and miRNA-mediated human gene expression. We have computationally predicted both miRNAs encoded by ZIKV able to target genes in the human genome and cellular (human) miRNAs capable of interacting with ZIKV genomes. Our results represent a step forward...Continue Reading


Jan 4, 2017·American Journal of Reproductive Immunology : AJRI·Newton Sérgio de CarvalhoLúcia de Noronha
Sep 13, 2019·Journal of Neurovirology·Rafael L RosaWalter O Beys-da-Silva
Nov 22, 2016·Current Opinion in Pediatrics·Claudia Raja Gabaglia
Aug 26, 2016·PLoS Neglected Tropical Diseases·Zachary A KlaseRobert Malone
Jul 25, 2019·Frontiers in Cellular and Infection Microbiology·Megan ChesnutDavid Pamies
Jan 8, 2020·Nucleic Acids Research·Yunqing LinDong Wang
Aug 29, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rajendra Gharbaran, Latchman Somenarain
Apr 27, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Shashank S PawitwarNazira El-Hage
Oct 11, 2017·Frontiers in Immunology·Ruth E DruryAndrew J Pollard


Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
Mar 15, 2006·Cell·Ronald H A Plasterk
Oct 24, 2006·Biochimica Et Biophysica Acta·Steven J SteinbergHugo W Moser
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Feb 28, 2009·BMC Bioinformatics·Sabah KadriPanayiotis V Benos
May 19, 2010·Annual Review of Microbiology·Rebecca L Skalsky, Bryan R Cullen
Feb 24, 2011·Current Molecular Medicine·T M WitkosW J Krzyzosiak
Jun 3, 2011·Trends in Cell Biology·Timothy L MegrawRichard S Nowakowski
Nov 26, 2011·Algorithms for Molecular Biology : AMB·Ronny LorenzIvo L Hofacker
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rodney P KincaidChristopher S Sullivan
Jan 12, 2013·PLoS Pathogens·Rodney P Kincaid, Christopher S Sullivan
Feb 9, 2013·Retrovirology·Zachary A KlaseFatah Kashanchi
Apr 11, 2013·The Journal of Biological Chemistry·Meghana GuptaDanny Manor
Dec 10, 2013·Nucleic Acids Research·Paul FlicekStephen M J Searle
Sep 26, 2015·Emerging Infectious Diseases·Didier Musso
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Apr 12, 2016·Science·Patricia P GarcezStevens K Rehen

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