Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice

Frontiers in Physiology
Meijuan LiuFengying Gong

Abstract

Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum andZAGmRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated the effects of ZAG administration on the body weight, body fat and glucose metabolism of high-fat diet (HFD)-induced obese ICR mice and the possible mechanisms involved. The results showed that serum ZAG and mRNA levels in sWAT were significantly decreased in overweight/obese patients and that both showed a negative association with body mass index (BMI) and body weight after adjustment for age and sex. Further partial correlation analysis found thatZAGmRNA expression was positively related with several WAT browning-related genes, including uncoupling protein 1 (UCP1) (r= 0.67) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1a) (r= 0.60), in the sWAT of all subjects. Additionally, intraperitoneal injection of a ZAG expression plasmid (5 μg/injection, four times a week) in HFD-induced obese mice for 8 weeks demonstrated that ZAG overexpression significantly decreased body weight and WAT m...Continue Reading

References

May 1, 1975·The Histochemical Journal·V R EdgertonD R Simpson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 5, 2002·British Journal of Cancer·S T RussellM J Tisdale
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Feb 27, 2004·Biochimica Et Biophysica Acta·Steven T RussellMichael J Tisdale
Mar 27, 2004·Physiological Reviews·Anindita NandiDomenico Accili
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Nov 17, 2006·Advances in Physiology Education·Huiyun Liang, Walter F Ward
Jan 20, 2007·FEBS Letters·Véronique RolliSeiamak Bahram
Apr 13, 2007·Physiological Reviews·David B SavageGerald I Shulman
Jun 25, 2009·The Journal of Clinical Endocrinology and Metabolism·Charles A StuartDeling Yin
Jul 22, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F-Y GongY-F Shi
Jul 23, 2009·The Journal of Clinical Endocrinology and Metabolism·David M SelvaRafael Simó
Dec 25, 2009·Endocrinology·Steven T Russell, Michael J Tisdale
Aug 11, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S T Russell, M J Tisdale
Oct 21, 2011·Physiological Reviews·Stefano Schiaffino, Carlo Reggiani
Jan 10, 2012·Biochimica Et Biophysica Acta·Steven Thomas Russell, Michael John Tisdale
Feb 4, 2012·Genes & Development·Ffolliott M FisherBruce M Spiegelman
Aug 21, 2012·Endocrinology·Steven T Russell, Michael J Tisdale
Oct 9, 2013·Nature Medicine·Matthew Harms, Patrick Seale
Nov 20, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S O'Neill, L O'Driscoll
Feb 18, 2015·Frontiers in Physiology·Anne-Laure PoherFrançoise Rohner-Jeanrenaud
Apr 17, 2015·Journal of Molecular Endocrinology·Hui Juan ZhuFeng Ying Gong
Oct 9, 2015·Cell Metabolism·Shingo KajimuraPatrick Seale
Sep 22, 2017·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Guoqiang FanXiaojing Yang

❮ Previous
Next ❯

Citations

Jul 15, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Xin-Hua XiaoJiang-Hua Liu
Apr 3, 2020·Journal of Physiology and Biochemistry·A RodríguezSara Becerril
Sep 10, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Meijuan LiuFengying Gong
May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitri PapukashviliYulin Deng
Apr 1, 2019·Biological Trace Element Research·Juliana Soares SeveroDilina do Nascimento Marreiro
Apr 9, 2020·Frontiers in Endocrinology·Linjie WangFengying Gong
Jan 27, 2021·Journal of Personalized Medicine·Olga I KiselevaElena A Ponomarenko

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
transfection
ELISA
light microscopy
PCR
Protein
protein assay

Software Mentioned

SPSS
ImageJ
Quantity One

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.