PMID: 6991653Jul 1, 1980Paper

Zinc absorption and its relationship to intestinal metallothionein

The Journal of Nutrition
B C StarcherJ G Madaras

Abstract

This study examined the relationship between zinc absorption and metallothionein. Mice injected intraperitoneally with ZnCl2 (2 mmoles) were found within 18 hours to have increased levels of intestinal metallothionein but an apparent decrease in 65Zn absorption. Induction of metallothionein with lower levels of ZnCl2 (0.2 or 0.5 mumoles) resulted in an apparent increase in 65Zn absorption. Isotope dilution experiments showed that intraperitoneal injections of 2 mumoles of ZnCl2 had resulted in a 500-fold dilution of the available 65Zn pool. Mild stress of the animals was shown to increase both 65Zn absorption and intestinal metallothionein. Actinomycin D administered 4 hours prior to ZnCl2 or stress, prevented the induction of metallothionein and obliterated the increase in 65Zn absorption. These results indicate that zinc absorption is directly proportional to intestinal metallothionein levels and imply a significant role for metallothionein in zinc absorption.

Citations

Dec 1, 1989·Biological Trace Element Research·M L AcklandH J McArdle
Mar 1, 1986·The British Journal of Nutrition·M J JacksonN D Carter
Dec 1, 1993·Journal of the American College of Nutrition·R A Wapnir, S Y Lee
Jan 1, 1994·Nutrition Research Reviews·J W SwinkelsM W Verstegen
May 1, 1984·Nutrition Reviews
Jan 1, 1982·The British Journal of Nutrition·N F SuttleA C Field
Jan 1, 1983·Journal of Inherited Metabolic Disease·R J Cousins
Mar 13, 2012·International Journal of Molecular Sciences·Muhammad Saleh SalgaSiddig Ibrahim Abdelwahab
Dec 1, 1985·Biological Trace Element Research·P ButzenB Starcher
May 23, 2017·The British Journal of Nutrition·Yu YuXu-Gang Luo
Dec 1, 1988·Nutrition Reviews·K M Hendricks, W A Walker
Mar 1, 1987·The British Journal of Nutrition·N I Berzin, V K Bauman
Jun 1, 1984·Biological Trace Element Research·M K SongM E Ament
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·M K Song
Mar 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·M K SongM E Ament

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