PMID: 8602590Mar 1, 1996Paper

Zinc absorption in premature infants: comparison of two isotopic methods

The American Journal of Clinical Nutrition
J K FrielH P Longerich

Abstract

The fractional absorption of an oral dose of zinc can be measured in adults when given simultaneously with an intravenous dose and subsequently measuring the ratio of the double isotopic enrichment of urine. To test this method in very-low-birth-weight (VLBW) premature infants [n=5 females and 7 males, 1160 +/- 290 g (chi +/- SD) birth weight, 29 +/- 4 wk gestational age], an oral dose of either 300 or 1200 micrograms 68Zn.kg(-1).d(-1) was equilibrated with formula or human milk and administered simultaneously with either 50 or 100 micrograms 70Zn.kg(-1).d(-1) given intravenously 35 +/- 3 wk postconception. Urine and fecal samples were collected for 3-6 d and analyzed by inductively coupled plasma mass spectrometry. Endogenous fecal zinc (EFZ) was determined from isotopic enrichment, whereas net absorption and retention were calculated by traditional methods. The mean fractional absorption calculated from urine was 0.22 +/- 0.09 and from feces it was 0.25 +/- 0.07. Zinc intake averaged 1821 +/- 330, fecal excretion 1637 +/- 419, and urinary excretion 67 +/- 30 micrograms.kg(-1).d(-1). EFZ averaged 390 +/- 270 micrograms.kg(-1).d(-1) and ranged from 48 to 889 micrograms.kg(-1).d(-1). Net absorption was 220 +/- 316 micrograms.kg(...Continue Reading

Citations

Feb 18, 1999·Pediatric Research·M E WastneyK N Subramanian
Nov 22, 2002·Food Additives and Contaminants·S J Fairweather-Tait, J Dainty
Jan 10, 2002·European Journal of Clinical Nutrition·G S YeungS H Zlotkin
Dec 3, 1999·The American Journal of Clinical Nutrition·S A Abrams
May 23, 2001·Experimental Biology and Medicine·K Y Patterson, C Veillon
Aug 1, 1996·Biological Trace Element Research·J K FrielH P Longerich
May 20, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Belal AlshaikhTanis Fenton

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