Zinc acclimation mitigated high zinc induced oxidative stress by enhancing antioxidant defenses in large yellow croaker Pseudosciaena crocea

Aquatic Toxicology
Jia-Lang ZhengLin Zeng

Abstract

The hypothesis tested in the present study was that Zn acclimation will alleviate high Zn induced oxidative stress in large yellow croaker Pseudosciaena crocea. To the end, fish were pre-exposed to 0 and 2mgZnL(-1) for 48h and then exposed to 0 and 10mgZnL(-1) for 48h. Lipid peroxidation, activities and mRNA levels of antioxidant enzyme genes (Cu/Zn-SOD, CAT, GPx and GR), and gene expressions of Nrf2-Keap1 signaling molecules at different exposure time (12h, 24h and 48h) were determined in the liver and spleen of large yellow croaker. 10mgZnL(-1) exposure alone enhanced lipid peroxidation in the liver during 12-48h and in the spleen during 24-48h. Although 2mgZnL(-1) pre-exposure did not affect lipid peroxidation, 2mgZnL(-1) pre-exposure mitigated high Zn induced oxidative stress. The positive effect of Zn acclimation could be attributed to the up-regulated expression and activities of antioxidant enzyme genes under high Zn stress. Obtained results also showed a coordinated transcriptional regulation of antioxidant genes, suggesting that Nrf2 is required for the protracted induction of these genes. Besides, the sharp increase in Keap1 expression levels would support its role in switching off Nrf2 response. In conclusion, Zn acc...Continue Reading

References

Nov 1, 1971·Analytical Biochemistry·C Beauchamp, I Fridovich
Feb 28, 2002·Molecular Cell·Tzu-Ching MengNicholas K Tonks
Aug 9, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Makoto KobayashiMasayuki Yamamoto
Jun 16, 2005·Aquatic Toxicology·Marlo K SellinAlan S Kolok
Apr 4, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Gülüzar AtliMustafa Canli
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Aug 31, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Fernanda Garcia SampaioFrancisco Tadeu Rantin
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul M CraigGrant B McClelland
Oct 11, 2007·The Journal of Biological Chemistry·Ok-Hee LeeAnil K Jaiswal
Jan 1, 2008·Mutation Research·William O Osburn, Thomas W Kensler
Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiongjie Shi, Bingsheng Zhou
Sep 21, 2010·Ecology Letters·David CostantiniPat Monaghan
Mar 3, 2011·Archives of Toxicology·Liam Baird, Albena T Dinkova-Kostova
May 28, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jeonghoon HanJae-Seong Lee
Aug 15, 2013·Marine Environmental Research·Francesco Regoli, Maria Elisa Giuliani
Nov 26, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Emmanouil E MalandrakisPanagiota Panagiotaki
Mar 7, 2015·Ecotoxicology and Environmental Safety·Francine F PalermoClaudia B R Martinez

❮ Previous
Next ❯

Citations

Jul 28, 2016·Fish & Shellfish Immunology·Jia-Lang ZhengChang-Wen Wu
Mar 25, 2021·Bulletin of Environmental Contamination and Toxicology·Changzhong LiWenjie Jin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.