PMID: 9438521Jan 23, 1998Paper

Zinc administration improves gastric alcohol dehydrogenase activity and first-pass metabolism of ethanol in alcohol-fed rats

Alcoholism, Clinical and Experimental Research
J CaballeríaJ Rodés

Abstract

The effects of zinc on first-pass metabolism (FPM) of ethanol and gastric and hepatic alcohol dehydrogenase (ADH) activities have been investigated in two groups of male Wistar rats fed a liquid ethanol diet with normal zinc content (7.6 mg/liter), or zinc supplemented (76 mg/liter), for 21 days, and in two pair-fed groups receiving the same diets without ethanol. Alcoholic rats with normal dietary zinc had lower FPM (1.64 +/- 0.25 vs. 2.43 +/- 0.20 mM x hr, p < 0.05) and gastric ADH activity (184 +/- 7 vs. 335 +/- 41 micromol/min/mg protein, p < 0.01) than control rats. Zinc supplementation did not produce any change in FPM or in gastric ADH activity in control rats. By contrast, in alcoholic rats, the zinc supplement increased gastric ADH activity (247 +/- 31 vs. 184 +/- 7 micromol/min/mg protein, p < 0.05) and decreased the areas under the curve of blood ethanol concentrations after the intragastric administration of 0.25 g/kg of body weight of ethanol (0.78 +/- 0.07 vs. 1.71 +/- 0.24 mM x hr, p < 0.05), thereby increasing the FPM. In conclusion, in alcohol-fed rats, the administration of zinc supplements restores gastric ADH activity and improves the FPM of ethanol. These effects may be one of the mechanisms in which zinc h...Continue Reading

References

Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GiménezJ Rodés
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·R Hernández-MuñozC S Lieber
Apr 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·Y IndoI Nakashima
Dec 1, 1986·Alcoholism, Clinical and Experimental Research·C J McClainS I Shedlofsky
Aug 24, 1987·Life Sciences·J CaballeriaC S Lieber
Nov 1, 1981·British Journal of Clinical Pharmacology·R E RangnoD S Sitar
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·K DohmenC S Lieber

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Citations

Nov 15, 2006·Digestive Diseases and Sciences·Pelin Arda-PirincciRefiye Yanardag
Dec 26, 2008·American Journal of Respiratory Cell and Molecular Biology·Pratibha C JoshiDavid M Guidot
Jul 10, 2007·American Journal of Obstetrics and Gynecology·Ridgely Fisk Green, Joan Marilyn Stoler

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