Zinc administration restores the impaired immune response observed in mice receiving excess copper by oral route

Immunopharmacology and Immunotoxicology
M PocinoL Baute

Abstract

To study if treatment with zinc (Zn) was able to restore to normal levels the depressed immune response determined by oral administration of excess copper (Cu), groups of mice receiving 100 ppm or 200 ppm of Cu in the drinking water for 8 weeks, were injected ip once a week with Zn (1.14 mg/kg of body weight), throughout the experimental period. Administration of Zn restored to normal levels the proliferative response to mitogens and the antibody response to sheep red blood cells in the group of mice receiving 100 ppm of Cu in the drinking water. Similarly, the treatment with Zn significantly enhanced the depressed proliferative response to mitogens and the antibody response to sheep red blood cells of mice receiving 200 ppm of Cu in the drinking water. By contrast, increment in Zn supply was not able to modify the high production of auto-antibodies observed in animals receiving excess Cu. The results suggest that the impairment of the immune response observed in animals receiving excess Cu could be in part due to antagonistic interactions between this cation and Zn.

References

Dec 9, 1978·Lancet·T U HoogenraadE G Korver
Sep 1, 1979·The Proceedings of the Nutrition Society·I Bremner
Nov 1, 1979·The Journal of Nutrition·K E Mason
Aug 1, 1979·Journal of Inorganic Biochemistry·A C HallI Bremner
Nov 1, 1976·The British Journal of Nutrition·I BremnerC F Mills
Jan 1, 1988·Critical Reviews in Food Science and Nutrition·R NathM Sharma
Feb 1, 1988·The Proceedings of the Nutrition Society·S SouthonT Hazell
May 1, 1987·The American Journal of Clinical Nutrition·L D KollerJ R Williams
Sep 1, 1986·Cellular Immunology·G L Warner, D A Lawrence
Oct 1, 1987·The Journal of Nutrition·B A ChowdhuryR K Chandra
Feb 1, 1985·The Journal of Nutrition·P Oestreicher, R J Cousins
Jun 1, 1985·Infection and Immunity·O A LukasewyczP Marder
Jan 1, 1974·Transplantation Reviews·N K JerneI Lefkovits
Jun 15, 1984·Toxicology and Applied Pharmacology·I Malavé, D T de Ruffino
Jan 1, 1983·Immunological Communications·I MalavéI R Benaím
Jan 1, 1983·Journal of Comparative Pathology·D G Jones, N F Suttle
May 1, 1980·Clinical Immunology and Immunopathology·S Cunningham-RundlesR A Good
Feb 1, 1982·The American Journal of Clinical Nutrition·W R Beisel
Jul 31, 1981·Science·J R Prohaska, O A Lukasewycz

❮ Previous
Next ❯

Citations

Jan 1, 1993·Molecular Aspects of Medicine·R Burrell
Aug 2, 2003·Chemosphere·Hana R PohlChristopher T De Rosa
Sep 30, 1999·Environmental Health Perspectives·P E Bigazzi
Feb 24, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H S Elsabbagh, O S El-Tawil
Jul 2, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Chih-Hung GuoTe-Cheng Yang
Apr 6, 2019·Current Medicinal Chemistry·Qingjun PanHua-Feng Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.