Zinc alpha2 glycoprotein protects against obesity-induced hepatic steatosis

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Xin-Hua XiaoJiang-Hua Liu

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, impaired insulin sensitivity, and chronic low-grade inflammation. Our previous studies indicated that zinc alpha2 glycoprotein (ZAG) alleviates palmitate (PA)-induced intracellular lipid accumulation in hepatocytes. This study is to further characterize the roles of ZAG on the development of hepatic steatosis, insulin resistance (IR), and inflammation. ZAG protein levels in the livers of NAFLD patients, high-fat diet (HFD)-induced or genetically (ob/ob) induced obese mice, and in PA-treated hepatocytes were determined by western blotting. C57BL/6J mice injected with an adenovirus expressing ZAG were fed HFD for indicated time to induce hepatic steatosis, IR, and inflammation, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations in these mice. The molecular mechanisms underlying ZAG-regulated hepatic steatosis were further explored and verified in mice and hepatocytes. ZAG expression was decreased in NAFLD patient liver biopsy samples, obese mice livers, and PA-treated hepatocytes. Simultaneously, ZAG overexpression alleviated intracellular lipid accumulation via upregulating adiponectin and lipo...Continue Reading

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Citations

Jun 27, 2020·Chinese Medical Journal·Xiao-Yan QiXin-Hua Xiao
Apr 9, 2020·Frontiers in Endocrinology·Linjie WangFengying Gong
Dec 3, 2020·International Journal of Molecular Sciences·Dóra KovácsDániel Törőcsik

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Methods Mentioned

BETA
ELISA
PCR
electrophoresis

Software Mentioned

ImagePro Plus
Statistical Package of Social Science ( SPSS
SPSS

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