PMID: 8964254Dec 1, 1995Paper

Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure

Ecotoxicology and Environmental Safety
C F PoloA M del C Batlle

Abstract

The correlation between blood lead level (BLL), delta-aminolevulinate dehydratase (ALA-D) activity, and other common biochemical parameters used to assess a plumbism diagnosis have been carefully analyzed, with the aim of correctly interpreting the data handled in the laboratory. No correlation was observed between BLL and free erythrocyte porphyrins. In the case of ALA-D or Zn-reactivated ALA-D despite the direct correlation with BLL, the curve follows a potential or a logarithmic line, which is not the best to calculate BLL. The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D. The plot of BLL against the iZn revealed a very good linear relationship which allows an estimate of BLL with reasonable accuracy within a very wide range.

Citations

Jul 27, 1999·Medizinische Klinik·M O DossI Sieg
Jan 16, 2015·Environmental Science and Pollution Research International·Chunhua LiuXijin Xu
May 8, 1998·Ecotoxicology and Environmental Safety·J L SantosR E Enríquez de Salamanca
Jul 6, 2010·Ecotoxicology and Environmental Safety·Paula E LombardiNoemí R Verrengia Guerrero

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