Zinc and atopic dermatitis: a systematic review and meta-analysis

Journal of the European Academy of Dermatology and Venereology : JEADV
N A GrayN P Khumalo

Abstract

Zinc plays a central role in skin integrity via barrier and immune mechanisms and may also be relevant in the pathogenesis of atopic dermatitis (AD). However, little is known about the relationship between zinc and AD. We performed a systematic review to determine (i) the association between zinc levels or zinc deficiency and AD and (ii) the efficacy of oral zinc supplementation in the treatment of AD. We searched PubMed, Scopus, Web of Science and article references for observational studies on zinc levels or zinc deficiency in participants with AD vs. controls and for randomized control trials (RCTs) on zinc supplementation in AD. For observational studies, we calculated pooled standardized mean differences (SMDs) or odds ratios (ORs) along with 95% confidence intervals (CIs) using a random effects model. We included 14 observational studies and two RCTs. The pooled SMD demonstrated significantly lower serum (SMD 0.66, 95% CI 0.21-1.10, P = 0.004), hair (SMD 0.95, 95% CI 0.38-1.52, P = 0.001) and erythrocyte (SMD 0.95, 95% CI 0.38-1.52, P = 0.001) zinc levels in participants with AD compared to controls. Pooled unadjusted data from three studies showed a non-significant increased odds of AD in those with zinc deficiency compa...Continue Reading

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Citations

Mar 12, 2020·Clinical Reviews in Allergy & Immunology·Chun-Min KangLi-Chieh Wang
Nov 23, 2020·Archives of Dermatological Research·Marissa T AyasseJonathan I Silverberg
Jan 5, 2021·PLoS Neglected Tropical Diseases·Marcin P Joachimiak
Feb 3, 2021·Auris, Nasus, Larynx·Masanobu SuzukiSarah Vreugde
Nov 1, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Masanobu SuzukiAkihiro Homma
Jun 20, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Esam HalboubAnas Shamala

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.