Zinc and gene expression

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
B L Vallee, K H Falchuk


During the last two decades, zinc has been shown to be a functionally essential component of more than 120 enzymes and concurrently has been recognized as indispensable to normal cellular growth, development and differentiation of all species. However, the manner in which it exerts its effects are still unknown. Studies of the phytid E. gracilis have demonstrated that zinc is critical for transcription and translation, affecting the metabolism of RNA polymerases, mRNA and proteins, among which are histones and arginine-containing peptides. These and other data lead to the suggestion that this element has a fundamental role in gene activation and/or repression, accounting for its pervasive effects on cell metabolism.


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Related Concepts

Amino Acyl-tRNA Synthetases
DNA Polymerase N3
Euglena gracilis
Histone H7
Structure-Activity Relationship
Transcription, Genetic
Protein Biosynthesis
Gene Activation

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