Zinc and gene expression

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
B L Vallee, K H Falchuk

Abstract

During the last two decades, zinc has been shown to be a functionally essential component of more than 120 enzymes and concurrently has been recognized as indispensable to normal cellular growth, development and differentiation of all species. However, the manner in which it exerts its effects are still unknown. Studies of the phytid E. gracilis have demonstrated that zinc is critical for transcription and translation, affecting the metabolism of RNA polymerases, mRNA and proteins, among which are histones and arginine-containing peptides. These and other data lead to the suggestion that this element has a fundamental role in gene activation and/or repression, accounting for its pervasive effects on cell metabolism.

Citations

May 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·L S Strochkova, A A Zhavoronkov
Jul 1, 1989·Bulletin of Environmental Contamination and Toxicology·N M BelmonteJ Herkovits
Jan 1, 1983·Journal of Inherited Metabolic Disease·J K Chesters
Jul 15, 1994·Experientia·R S Bedwal, A Bahuguna
Mar 1, 1985·Biological Trace Element Research·I E DreostiS J Manuel
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·P G Paterson, W J Bettger
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P Cenini
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·E PiccinniL Guidolin
Jan 1, 1985·Pediatric Neurology·A W ZimmermanE Horak
Jan 1, 1990·Free Radical Biology & Medicine·T M Bray, W J Bettger
Apr 27, 2013·Experimental Eye Research·Ivan AnastassovRichard L Chappell
Dec 13, 2000·Brain Research. Brain Research Reviews·Atsushi Takeda
Nov 13, 2004·The Journal of Nutritional Biochemistry·J K Chesters, L Petrie
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B L ValleeD S Auld
May 1, 1985·The British Journal of Nutrition·S SouthonI T Johnson
Nov 1, 1985·The British Journal of Nutrition·S WambergP Stigsen
Aug 1, 1984·European Journal of Biochemistry·P Zahradka, K Ebisuzaki
Aug 9, 2003·Drug Development and Industrial Pharmacy·Jinrong LiuLane J Brunner
Aug 1, 1985·Clinics in Endocrinology and Metabolism·D M Danks
Oct 25, 1983·Biochemistry·A StankiewiczB L Vallee
Feb 9, 1993·Biochemistry·M CzuprynB L Vallee
Jan 27, 2005·Neurochemistry International·Atsushi TakedaNaoto Oku
Jan 1, 1995·Metabolism: Clinical and Experimental·S R KimballA E Leure-duPree
Jul 1, 1984·Toxicology and Applied Pharmacology·P L Goering, C D Klaassen
Jul 1, 1994·Microscopy Research and Technique·C M PayneO Bohnert
Aug 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe Arena, Enrico Rizzarelli
May 1, 1986·The British Journal of Nutrition·S SouthonI T Johnson
Jul 31, 1999·FEBS Letters·A SakuraiN Imura

Related Concepts

Amino Acyl-tRNA Synthetases
DNA Polymerase N3
Euglena gracilis
Histone H7
Transcriptase
Structure-Activity Relationship
Transcription, Genetic
Protein Biosynthesis
Zinc
Gene Activation

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