Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Diana StoyeDirk Reinhold

Abstract

Zinc is an essential trace element with a critical role in normal growth and development and in immune homeostasis. Zinc deficiency impairs both the innate and the adaptive immune system and can be normalized by zinc supplementation. On the other end of the spectrum, high dosages of zinc diminish immune cell functions similar to zinc deficiency. Here, we investigated the influence of zinc aspartate on proliferation and cytokine production of stimulated human T cells and mouse splenocytes in vitro. Furthermore, the effect of zinc aspartate was examined in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of Multiple Sclerosis (MS) with a Th1/Th17 T cell-mediated immunopathogenesis. Zinc aspartate suppressed proliferation as well as IL-2, IL-10 and IL-17 production in stimulated human T cells and mouse splenocytes. Importantly, administration of a medium range dose of 30 μg/day zinc aspartate [1.5 mg/kg body weight (BW)] in a therapeutic manner led to a significant reduction of the clinical severity of the EAE during the first relapse of the disease. A lower zinc aspartate dose (6 μg/day, 0.3 mg/kg BW) had no significant therapeutic effect on the severity of the EAE, while administration of higher zinc as...Continue Reading

References

Oct 8, 1977·Lancet·K G PorterA H Love
Nov 10, 1978·JAMA : the Journal of the American Medical Association·A S PrasadP Rabbani
Jan 1, 1990·Free Radical Biology & Medicine·T M Bray, W J Bettger
Jan 1, 1990·Annual Review of Nutrition·C L Keen, M E Gershwin
Feb 1, 1990·The American Journal of Clinical Nutrition·G J Fosmire
Dec 1, 1981·In Vitro·D H Hoscheit
Jun 1, 1996·Methods : a Companion to Methods in Enzymology·S BrockeL Steinman
Aug 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I CakmanL Rink
Dec 5, 1997·Immunology Today·N WellinghausenL Rink
Nov 21, 1998·Journal of Leukocyte Biology·N Wellinghausen, L Rink
Mar 31, 1999·Immunology Today·D ReinholdK Grüngreiff
Aug 17, 2000·The Journal of Infectious Diseases·A S Prasad
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SteinbrecherS Brocke
Apr 25, 2001·Biological Trace Element Research·C A CampoL Rink
Jan 30, 2004·Lancet Neurology·David A DymentA Dessa Sadovnick
Sep 29, 2004·Free Radical Biology & Medicine·Ananda S PrasadFazlul H Sarkar
Oct 4, 2005·Journal of Neuroimmunology·Kandace K FlemingJanet G Marquis
Jun 20, 2006·Immunity·Casey T WeaverKenneth M Murphy
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka KomiyamaYoichiro Iwakura
Aug 26, 2006·Nature Clinical Practice. Neurology·Bernhard HemmerHans-Peter Hartung
Oct 19, 2006·European Journal of Immunology·Till A RöhnMartin F Bachmann
Oct 19, 2006·European Journal of Immunology·Catherine Uyttenhove, Jacques Van Snick
Nov 28, 2006·Trends in Immunology·Lothar Rink, Hajo Haase
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Harald H HofstetterPaul V Lehmann
Mar 9, 2007·The American Journal of Clinical Nutrition·Ananda S PrasadLavoisier J Cardozo
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
May 16, 2007·The Journal of Cell Biology·Satoru YamasakiToshio Hirano
Jan 2, 2008·Experimental Gerontology·Peter UciechowskiLothar Rink
Feb 6, 2008·Experimental Gerontology·Audrey VarinTamas Fulop
Dec 17, 2008·The Journal of Clinical Investigation·Stefan HaakAri Waisman
Mar 5, 2010·European Journal of Immunology·Jennifer KaltenbergHajo Haase
Mar 11, 2010·International Immunology·Chika KitabayashiToshio Hirano
Mar 23, 2011·The Journal of Experimental Medicine·Mingcan YuJörg J Goronzy
Jun 11, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Toshiyuki FukadaToshio Hirano

❮ Previous
Next ❯

Citations

Feb 18, 2014·Metallomics : Integrated Biometal Science·Hajo Haase, Lothar Rink
Jul 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Martina Maywald, Lothar Rink
Aug 26, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Claudia SchubertDirk Reinhold
Dec 2, 2014·Pharmacology & Therapeutics·Katja SchmitzIrmgard Tegeder
Apr 10, 2013·Neuroscience and Biobehavioral Reviews·Walter SwardfagerKrista L Lanctôt
Feb 21, 2016·The Journal of Nutritional Biochemistry·Eva RosenkranzLothar Rink
Nov 29, 2015·Molecular Nutrition & Food Research·Eva RosenkranzLothar Rink
Nov 22, 2015·European Journal of Nutrition·Eva RosenkranzLothar Rink
Jun 11, 2016·ASN Neuro·Mikkel Bredholt, Jette Lautrup Frederiksen
Dec 16, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia Colomar-CarandoRubén Vicente
Mar 6, 2019·Molecular and Cellular Biology·Jochen Michael RudolphAnnegret Reinhold
Aug 23, 2017·Nature Communications·Satish RanjanBerend Isermann
Oct 22, 2019·Frontiers in Immunology·Jochen RudolphAnnegret Reinhold
Apr 4, 2021·Biomedicines·Dirk ReinholdAnnegret Reinhold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved