PMID: 18214192Jan 25, 2008Paper

Zinc cream and reliability of tuberculosis skin testing.

Emerging Infectious Diseases
V Bhargavi RaoCarlton A Evans

Abstract

In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.

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