Zinc deficiency: An unexpected trigger for autophagy.

The Journal of Biological Chemistry
Binbin Ding, Qing Zhong

Abstract

Cells respond to deprivation of certain nutrients such as glucose or nitrogen by inducing autophagy, reclaiming pieces of proteins for use in critical functions. A recent study shows that, in yeast, zinc depletion acts in a similar fashion. Depletion of this essential nutrient induces non-selective autophagy by inhibiting TORC1, leading to release and recycling of zinc from degraded proteins.

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Citations

Dec 21, 2018·International Journal of Molecular Sciences·Karl KernsPeter Sutovsky
May 3, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Thomas D Lockwood
May 31, 2019·Medicina·Nursyuhada Azzman
Jul 19, 2020·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Apr 11, 2020·Redox Biology·Juan Diego Hernández-CamachoIgnacio Navas-Enamorado
Mar 12, 2021·Journal of Cellular Physiology·Yuping LuoMin Li
Jun 12, 2021·Frontiers in Immunology·Tamiris Lameira BittencourtRoberta Olmo Pinheiro

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