Zinc deficiency and activities of lipogenic and glycolytic enzymes in liver of rats fed coconut oil or linseed oil

Lipids
K Eder, M Kirchgessner

Abstract

In previous studies, zinc-deficient rats force-fed a diet with coconut oil as the major dietary fat developed a fatty liver, whereas zinc-deficient rats force-fed a diet with linseed oil did not. The present study was conducted to elucidate the reason for this phenomenon. In a bifactorial experiment, rats were fed zinc-adequate or zinc-deficient diets containing either a mixture of coconut oil (70 g/kg) and safflower oil (10 g/kg) ("coconut oil diet") or linseed oil (80 g/kg) ("linseed oil diet") as a source of dietary fat, and activities of lipogenic and glycolytic enzymes in liver were determined. In order to ensure adequate food intake, all the rats were force-fed. Zinc-deficient rats on the coconut oil diet developed a fatty liver, characterized by elevated levels of triglycerides with saturated and monounsaturated fatty acids. These rats also had markedly elevated activities of the lipogenic enzymes acetyl-CoA carboxylase, fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH), and citrate cleavage enzyme, whereas activities of malic enzyme and glycolytic enzymes were not different compared with zinc-adequate rats on the coconut oil diet. In contrast, rats receiving t...Continue Reading

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Citations

Aug 1, 1996·Biological Trace Element Research·K Eder, M Kirchgessner
Apr 11, 2002·Lipids·N N GomezM S Gimenez
May 23, 2013·Biological Trace Element Research·Xinwei LiGuowen Liu
Oct 25, 2008·The British Journal of Nutrition·Kelly A JacksonDianne Ford
Aug 21, 2004·Biological Chemistry·Hannelore Daniel, Heike tom Dieck
Jul 7, 2011·International Journal of Molecular Sciences·María S GimenezNidia N Gomez
May 12, 1998·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A VilletA Favier
May 21, 2008·Proteomics·John H BeattieIn-Sook Kwun
Jun 8, 2012·Journal of Animal Physiology and Animal Nutrition·E Weigand, C Boesch-Saadatmandi
Dec 22, 2006·The British Journal of Nutrition·Nidia Noemí GomezMaría Sofía Gimenez
Apr 4, 2003·The Journal of Nutrition·Heike tom DieckHannelore Daniel

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