Zinc deficiency and host response to helminth infection: Echinostoma caproni infections in CBA mice

Journal of Helminthology
J BaekN O Christensen

Abstract

The effect of zinc deficiency on the response of CBA mice to infection with the intestinal trematode Echinostoma caproni was examined. Young CBA mice were allocated to one of three dietary groups: a group fed a zinc deficient diet ad libitum, a control group pair fed a zinc sufficient diet and a control group fed a zinc sufficient diet ad libitum. The mice on the zinc deficient diet gained significantly less weight than the pair fed controls. In primary infections with six E. caproni metacercariae followed over a period of 128 days, zinc deficiency delayed worm expulsion. In addition, zinc deficiency resulted in a prolonged IgM response, a delayed IgG response and an increased IgA response towards the end of the experiment. Resistance to challenge infection day 21 following a primary infection with 25 E. caproni metacercariae was slightly, but not significantly, affected by zinc deficiency.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Oct 1, 1977·The Journal of Nutrition·P J FrakerR W Luecke
Jan 1, 1990·Advances in Parasitology·J E Huffman, B Fried
Feb 1, 1990·International Journal for Parasitology·B Fried, K R Sousa
Jul 1, 1990·The American Journal of Clinical Nutrition·P K FenwickD Wakelin
Jul 1, 1990·The American Journal of Clinical Nutrition·P K FenwickD Wakelin
Oct 1, 1989·The Journal of Nutrition·H M el-HagD Wakelin
Jan 1, 1988·Parasitology Research·N O ChristensenP E Simonsen
Dec 1, 1987·Parasitology·D A Bundy, M H Golden
Oct 1, 1986·International Journal for Parasitology·P E Simonsen, B J Andersen
May 1, 1986·The British Journal of Nutrition·S SouthonI T Johnson
Jun 1, 1986·Experimental Parasitology·N O ChristensenJ Andreassen

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Citations

May 6, 2003·The Journal of Nutrition·Richard W Steketee

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