PMID: 9430600Jan 31, 1998Paper

Zinc deficiency changes preferred macronutrient intake in subpopulations of Sprague-Dawley outbred rats and reduces hepatic pyruvate kinase gene expression

The Journal of Nutrition
K J KennedyN F Shay

Abstract

Macronutrient selection patterns of male rats were analyzed using a 3-choice macronutrient selection system providing either adequate (+Zn) or deficient (-Zn) levels of zinc (30 or 1 mg Zn/kg). In study 1, rats were provided +Zn and -Zn diets for 28 d. All rats preferred carbohydrate (>50% carbohydrate intake) at the onset, consuming an average of 71% carbohydrate (cho), 17% protein (pro), and 12% fat. By the end of the study, 25% of the -Zn rats switched preference from cho to fat, whereas no +Zn rats changed. In study 2, -Zn rats preferring fat increased their total intake to normal levels, but only 50% reverted to carbohydrate preference after 35 d of zinc repletion. Hypothalamic concentrations of galanin were measured in groups of +Zn and -Zn cho- and fat-preferring rats. Galanin, which may be regulated with fat intake, was not different in -Zn rats preferring fat vs. -Zn rats preferring cho. Galanin concentrations were higher in +Zn than in -Zn rats (P < 0.05) and higher in +Zn rats preferring fat than in +Zn rats preferring cho (P < 0.05). Hepatic pyruvate kinase (PK) mRNA concentrations were related to cho preference, regardless of zinc status. When PK mRNA levels were measured in rats consuming a single AIN- 93-based di...Continue Reading

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Citations

Sep 25, 2001·Experimental Biology and Medicine·E S Ott, N F Shay
Dec 7, 2002·International Journal of Adolescent Medicine and Health·Pia P Tannhauser
Apr 17, 2007·Biological Trace Element Research·Ming-Yan JingXiao-Yan Weng
Aug 21, 2004·Biological Chemistry·Hannelore Daniel, Heike tom Dieck
Sep 19, 2009·Journal of Nutritional Science and Vitaminology·Yoko HorikawaNanaya Tamaki
Apr 23, 2011·Journal of Nutritional Science and Vitaminology·Yoko HorikawaNanaya Tamaki
Sep 29, 2011·Biological Trace Element Research·Julie Calixto LoboDenise Mafra
Sep 1, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Elena Alvarez-SalasPatricia de Gortari
Feb 2, 2002·The Journal of Nutrition·Carolyn E HuntingtonJ Lee Beverly
Jul 19, 2008·Journal of Nutritional Science and Vitaminology·Yoko HorikawaNanaya Tamaki
Jul 20, 2006·Cell Biochemistry and Function·Abdulkerim Kasim BaltaciOktay Kaya
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A Van Gossum, J Neve
Apr 4, 2002·Nutritional Neuroscience·A C ColeJ L Beverly
May 10, 2000·The Journal of Nutrition·N F Shay, H F Mangian
Apr 25, 2000·Biochemical and Biophysical Research Communications·M A Jankowski-HennigC L Keen
Jul 27, 2021·Domestic Animal Endocrinology·M Sadegzadeh-SadatS Asri-Rezaei

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