PMID: 9649590Jul 3, 1998Paper

Zinc deficiency enhances interleukin-1alpha-induced metallothionein-1 expression in rats

The Journal of Nutrition
L CuiA Okada

Abstract

This study investigated whether interleukin-1alpha-induced metallothionein gene expression is affected by zinc deficiency. Weaning male rats were fed a zinc-deficient (ZD) diet (2 mg zinc/kg) or a zinc-supplemented diet [50.8 mg zinc/kg; controls for the diet included pair-fed (PF) and ad libitum consumption groups (AL)] for 4 wk. All rats except those that served as controls for interleukin-1alpha administration, (injected with vehicle and killed at 0 h) were then injected subcutaneously with interleukin-1alpha (2 x 10(7) units/kg body wt) and killed at 3, 6, 12, 24 and 72 h after the injection. Compared with AL and/or PF rats, zinc depletion significantly reduced zinc concentrations in plasma and liver but not in kidney or intestine, and significantly reduced hepatic, renal, and intestinal metallothionein-1 mRNA levels analyzed by competitive reverse transcription-polymerase chain reaction (RT-PCR). Interleukin-1alpha injection reduced plasma zinc concentration and enhanced liver zinc concentration, but did not affect zinc levels in kidney or intestine. Metallothionein-1 mRNA was significantly elevated by interleukin-1alpha in liver, kidney and intestine of all groups; the levels in liver and kidney of ZD rats 6 h after the i...Continue Reading

References

Aug 1, 1992·Nutrition Reviews·J K Chesters
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·M T Ercan, N M Bor
Oct 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J Cousins, A S Leinart
Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·Y TakagiY Kawashima
Jun 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·M A DunnR J Cousins
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K G DanielsonP C Huang
Jul 1, 1994·Clinical Immunology and Immunopathology·J E SimsS K Dower
Mar 8, 1996·Chemico-biological Interactions·J HernandezJ Hidalgo
Dec 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T TakiiK Onozaki
Apr 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·J ThurN Hunzelmann

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Citations

Aug 30, 2008·Experimental Aging Research·Güler OztürkLale Afrasyap
Jul 12, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Juan P LiuzziTiffanie S Stewart
May 10, 2000·The Journal of Nutrition·E Mocchegiani, M Muzzioli
Sep 18, 2001·Equine Veterinary Journal·G StarkM Gemeiner
Oct 16, 2007·Digestive Diseases and Sciences·Praveen RishiAshwani Koul
Jan 1, 2003·Bioscience, Biotechnology, and Biochemistry·Komang Ayu NocianitriYoritaka Aoyama
Aug 10, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·L Cui, A Okada
Nov 4, 2016·American Journal of Physiology. Cell Physiology·Mirandy S LiClintoria R Williams
Mar 20, 2010·Archives of Environmental Contamination and Toxicology·Mohamed BanniKhaled Said
May 9, 2002·Burns : Journal of the International Society for Burn Injuries·H Q DingS Cheng
Dec 29, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A V Kudrin
Oct 13, 2006·Experimental Gerontology·Eugenio MocchegianiMarco Malavolta

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