Abstract
Three-choice macronutrient intake studies indicate that zinc-deficient (Zn-) rats selectively decrease intake of carbohydrate. Because glucoprivic stimuli increase food intake and selection for carbohydrate, the ability of Zn- rats to respond to glucoprivation induced by 2-deoxy-D-glucose (2-DG) was tested. Rats were fed a Zn-adequate (Zn+) or Zn- diet. In part 1, rats were challenged with 0, 250, or 400 mg 2-DG/kg BW (i.p.) after zinc deficiency was established. In part 2, rats received saline or 2-DG while zinc deficiency was being induced and then after deficiency was established. Food intake was increased after injection of 2-DG to Zn+ rats; however, food intake was not higher after 2-DG administration to Zn- rats. A dose-response test for 2-DG further confirmed these results. In part 2, it was found that Zn- rats lose the response to 2-DG administration when zinc deficiency-induced anorexia begins, after 3 days of consuming a zinc-deficient diet. It appears that the ability to sense blood glucose concentrations may be impaired during zinc deficiency, and this impairment could be a part of the anorexia that develops during zinc deficiency in the rat.
References
Jun 30, 1978·Brain Research·S RitterR C Ritter
May 1, 1992·Physiology & Behavior·E Delprete, E Scharrer
Dec 1, 1990·Brain Research Bulletin·D L Tempel, S F Leibowitz
Sep 1, 1991·Brain Research Bulletin·S F Leibowitz
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·G Shor-PosnerS F Leibowitz
Nov 1, 1985·Peptides·B G StanleyS F Leibowitz
Jun 1, 1985·Brain Research Bulletin·S F LeibowitzJ B Tretter
Sep 1, 1973·Journal of Neurochemistry·R W HortonH S Bachelard
Oct 1, 1972·The American Journal of Physiology·E E MüllerP Mantegazza
Mar 1, 1984·Physiology & Behavior·M B EssataraJ E Morley
Apr 1, 1984·The Journal of Nutrition·P G Reeves, B L O'Dell
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R B KanarekL Gualtieri
Mar 1, 1982·The Journal of Nutrition·J C WallworkH H Sandstead
Nov 1, 1993·The Journal of Nutrition·P G ReevesG C Fahey
Sep 10, 1993·Brain Research·A AkabayashiS F Leibowitz
Nov 1, 1995·Brain Research. Molecular Brain Research·S MinamiI Wakabayashi
Jan 1, 1997·Journal of Neuroendocrinology·P L SelvaisD M Maiter
Jan 31, 1998·The Journal of Nutrition·K J KennedyN F Shay
May 2, 1998·Brain Research·B HeR J Martin
Jun 24, 1998·Brain Research·S Q GiraudoA S Levine
Jul 3, 1998·The Journal of Nutrition·R G LeeN F Shay
Nov 12, 1998·Physiology & Behavior·L K SingerG A Bray
Feb 23, 2000·Neuroreport·V SergeyevT Hökfelt
Sep 25, 2001·Experimental Biology and Medicine·E S Ott, N F Shay