Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update

Current Medicinal Chemistry
Faria SultanaAhmed Kamal

Abstract

Histone deacetylases (HDAC) are an important class of enzymes that play a pivotal role in epigenetic regulation of gene expression that modifies the terminal of core histones leading to remodelling of chromatin topology and thereby controlling gene expression. HDAC inhibitors (HDACi) counter this action and can result in hyperacetylation of histones, thereby inducing an array of cellular consequences such as activation of apoptotic pathways, generation of reactive oxygen species (ROS), cell cycle arrest and autophagy. Hence, there is a growing interest in the potential clinical use of HDAC inhibitors as a new class of targeted cancer therapeutics. Methodology and Result: Several research articles spanning between 2016 and 2017 were reviewed in this article and presently offer critical insights into the important strategies such as structure-based rational drug design, multi-parameter lead optimization methodologies, relevant SAR studies and biology of various class of HDAC inhibitors, such as hydroxamic acids, benzamides, cyclic peptides, aliphatic acids, summarising the clinical trials and results of various combination drug therapy till date. This review will provide a platform to the synthetic chemists and biologists to cate...Continue Reading

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Oct 31, 2019·SLAS Discovery·Rosita R AsawaNatalia J Martinez
Aug 20, 2020·Seminars in Cancer Biology·Margarita E NeganovaGjumrakch Aliev
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyo-Seon LeeSyng-Ook Lee
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ameen Ali Abu-HashemMagdi E A Zaki
Jul 3, 2021·Cells·Rosa Lynn SchmitzSebastian Krug

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