Zinc does not acutely suppress prolactin in normal or hyperprolactinemic women

The Journal of Clinical Endocrinology and Metabolism
M C KoppelmanP Deuster

Abstract

In rat pituitary cells in vitro physiological zinc concentrations selectively inhibit basal and stimulated PRL release. This study was done to investigate the serum PRL response to an oral zinc challenge in vivo. Eight hyperprolactinemic [mean serum PRL, 76.0 +/- 43.8 (+/- SD) micrograms/L] and 10 normal (mean serum PRL, 9.6 +/- 2.8 micrograms/L) women were studied. All women had normal thyroid, renal, and hepatic function, and none was taking any medications. Each was studied twice, after both oral zinc (50 mg) and placebo, given in random order. Blood was withdrawn every 15 min from 30 min before to 210 min after zinc or placebo administration; TRH (500 micrograms) was given iv at 180 min. Both hyperprolactinemic and normal women absorbed the zinc well, achieving similar maximal plasma zinc levels [hyperprolactinemic women, 39.5 +/- 6.9 (+/- SD) mumol/L; normal women, 33.3 +/- 7.0; P less than 0.001 vs. placebo]. When 2 women who became symptomatic after zinc administration were excluded, there were no significant differences in basal or TRH-stimulated serum PRL levels after zinc vs. placebo. These findings indicate that zinc is not involved in the acute in vivo regulation of PRL secretion in humans.

Citations

Aug 1, 1995·Biological Trace Element Research·J Brandão-NetoA V Castro
May 5, 2007·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Caitlin E O'BrienFang Dong
Jan 1, 1992·Biological Trace Element Research·J Neve
May 19, 2000·The Journal of Biological Chemistry·Q R FanD C Wiley

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