Zinc enhances ethanol modulation of the alpha1 glycine receptor.

Neuropharmacology
Lindsay M McCrackenS John Mihic

Abstract

Glycine receptor function mediates most inhibitory neurotransmission in the brainstem and spinal cord and is enhanced by alcohols, volatile anesthetics, inhaled drugs of abuse, and endogenous compounds including zinc. Because zinc exists ubiquitously throughout the brain, investigations of its effects on the enhancement of GlyR function by alcohols and anesthetics are important to understanding the effects of these agents in vivo. In the present study, the effects of zinc plus ethanol, pentanol, or isoflurane were tested on homomeric alpha1 glycine receptors to determine if concurrent applications of physiological concentrations of zinc with each of these modulators changed the magnitude of their effects. Homomeric alpha1 glycine receptors were expressed in Xenopus laevis oocytes, and the two-electrode voltage-clamp technique was used to measure glycine-mediated currents in the presence of combinations of zinc with ethanol, pentanol or isoflurane. The combined effects of zinc plus ethanol were greater than the sum of the effects produced by either compound alone. However, this was not seen when zinc was combined with either pentanol or isoflurane. Chelation of zinc by tricine decreased the effects of sub-maximal, but not maxima...Continue Reading

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Citations

Nov 1, 2011·The Journal of Pharmacology and Experimental Therapeutics·Cecilia M BorgheseR Adron Harris
Dec 12, 2012·The Journal of Pharmacology and Experimental Therapeutics·Lindsay M McCrackenR Adron Harris
Nov 2, 2013·Brain Research Bulletin·Garrett L Cornelison, S John Mihic
Jul 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlos F BurgosLuis G Aguayo
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Brian T WelshS John Mihic
May 15, 2015·Alcoholism, Clinical and Experimental Research·Suzzane HoraniRebecca J Howard
Feb 28, 2015·Brain Research·Nicole-Marie M Farley, S John Mihic
Jul 13, 2016·Molecular Pharmacology·Carlos F BurgosLuis G Aguayo
Nov 28, 2017·European Journal of Nutrition·Anatoly V SkalnyAlexey A Tinkov
Jan 15, 2017·The Journal of Pharmacology and Experimental Therapeutics·Garrett L CornelisonS John Mihic
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Bo SöderpalmMia Ericson
Nov 15, 2019·Alcoholism, Clinical and Experimental Research·Joydip Das
Jul 31, 2013·Alcoholism, Clinical and Experimental Research·Lindsay M McCrackenR Adron Harris
Jun 25, 2020·Biochemical Pharmacology·Casey I GallagherRobert J Vandenberg

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