Zinc finger antiviral protein inhibits coxsackievirus B3 virus replication and protects against viral myocarditis

Antiviral Research
Min LiWei Xu

Abstract

The host Zinc finger antiviral protein (ZAP) has been reported exhibiting antiviral activity against positive-stranded RNA viruses (Togaviridae), negative-stranded RNA viruses (Filoviridae) and retroviruses (Retroviridae). However, whether ZAP restricts the infection of enterovirus and the development of enterovirus mediated disease remains unknown. Here, we reported the antiviral properties of ZAP against coxsackievirus B3 (CVB3), a single-stranded RNA virus of the Enterovirus genus within the Picornaviridae as a major causative agent of viral myocarditis (VMC). We found that the expression of ZAP was significantly induced after CVB3 infection in heart tissues of VMC mice. ZAP potently inhibited CVB3 replication in cells after infection, while overexpression of ZAP in mice significantly increased the resistance to CVB3 replication and viral myocarditis by significantly reducing cardiac inflammatory cytokine production. The ZAP-responsive elements (ZREs) were mapped to the 3'UTR and 5'UTR of viral RNA. Taken together, ZAP confers resistance to CVB3 infection via directly targeting viral RNA and protects mice from acute myocarditis by suppressing viral replication and cardiac inflammatory cytokine production. Our finding further...Continue Reading

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Citations

Dec 23, 2016·Japanese Journal of Infectious Diseases·Jia-Lu YuGen Lu
Feb 9, 2019·Journal, Genetic Engineering & Biotechnology·Abd El-Moneim M R AfifySoha A Murad
Feb 8, 2020·Genes & Development·Anthony R FehrMasanori Aikawa
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Aug 21, 2019·Cells·Louis BergantzClémence Richetta
Dec 29, 2020·Frontiers in Immunology·Emily Yang, Melody M H Li
Apr 4, 2021·Viruses·Mathilde MalgrasNicolas Lévêque
May 22, 2021·Biochemical and Biophysical Research Communications·Rongrong ZhangHuabin Shao
Jun 16, 2021·Annual Review of Virology·Mattia FicarelliChad M Swanson

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