Zinc finger-like motif conserved in a family of RNA binding proteins

Bioscience, Biotechnology, and Biochemistry
Y MatsushimaY Kitagawa

Abstract

NP220s compose a family of RNA binding proteins together with matrin 3, one of major proteins of the nuclear matrix. They have repeats of RNA recognition motif (RRM; MH2) homologous to RRM in heterogeneous nuclear RNPs I/L in addition to MH1 and MH3 with unknown function. In search of additional homologous sequences, we found the reported sequence of rat matrin 3 is partially incorrect. Correction of this sequence showed that the NP220 family has a fourth homologous motif with the characteristics of a Cys2-His2 zinc finger-like motif. The sequence of this motif is perfectly conserved in human and mouse NP220s despite their 75% overall sequence homology.

Citations

May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M LittleP Walsh
Jan 29, 2002·Journal of Cellular Biochemistry·Enders Kai On NgKwok Pui Fung
Sep 29, 1999·Genes & Development·P FortesI W Mattaj
Jun 10, 2000·Molecular and Cellular Biology·E LalliP Sassone-Corsi
Jul 31, 2007·Biochemical and Biophysical Research Communications·C Alexander ValenciaRihe Liu
Jul 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Douglas M AndersonEric N Olson
Oct 3, 1998·Bioscience, Biotechnology, and Biochemistry·K OkumaraY Kitagawa
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J ZhangA J D'Ercole
Nov 6, 2007·The Journal of Biological Chemistry·Isao KuraokaKiyoji Tanaka
Dec 22, 2006·Journal of Cell Science·Justin F-X AinscoughDawn Coverley
Oct 26, 1999·Biochemical and Biophysical Research Communications·K MitsuiA Yoshimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved