PMID: 11179890Feb 17, 2001Paper

Zinc finger proteins: new insights into structural and functional diversity

Current Opinion in Structural Biology
J H LaityP E Wright


Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding. Zinc finger structures are as diverse as their functions. Structures have recently been reported for many new zinc finger domains with novel topologies, providing important insights into structure/function relationships. In addition, new structural studies of proteins containing the classical Cys(2)His(2) zinc finger motif have led to novel insights into mechanisms of DNA binding and to a better understanding of their broader functions in transcriptional regulation.


Jan 1, 1990·Annual Review of Biophysics and Biophysical Chemistry·J M Berg
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Aug 1, 1997·Nature Structural Biology·M P FosterP E Wright
Dec 17, 1997·Nature Genetics·S BarbauxK McElreavey
Jul 8, 1999·Molecular Cell·T G KutateladzeM Overduin
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·C D MackerethL P McIntosh
Aug 10, 2000·The Journal of Biological Chemistry·C SunS W Fesik
Sep 12, 2000·Current Opinion in Structural Biology·Y Choo, M Isalan
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