Zinc fingers as biologic redox switches?

Antioxidants & Redox Signaling
Klaus-D Kröncke, Lars-Oliver Klotz

Abstract

Despite zinc ions being redox inert in biologic systems, zinc-finger structures act as redox-sensitive molecular switches controlling several crucial cellular processes. Oxidative or nitrosative stress, via modification of zinc finger cysteine thiols, leads to a release of Zn(2+) from these structures, causing not only a loss of zinc-finger function but also an increase of cytoplasmic or nuclear free Zn(2+) that may, in turn, stimulate and interfere with cellular signaling cascades. A signaling cascade stimulated by exposure of cells to zinc ions or to stressful stimuli that are reported to cause an intracellular release of zinc ions involves phosphoinositide 3'-kinases and the Ser/Thr protein kinase Akt, resulting in an inactivation of transcriptional regulators of the FoxO family. Possible modes of action of zinc ions to stimulate this signaling cascade and consequences of stimulation are discussed. Moreover, we present an overview on human diseases or disorders characterized by an intracellular Zn(2+) dyshomeostasis.

References

Dec 1, 1985·Toxicology Letters·S V RanaC B Sharma
Jan 1, 1981·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M E TolbertG D Draper
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Sep 16, 1999·Archives of Biochemistry and Biophysics·K TakakuraJ P Crow
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·L L PearceE S Levitan
Feb 19, 2000·The American Journal of Clinical Nutrition·Y Christen
May 9, 2000·The Journal of Biological Chemistry·X WangN J Holbrook
Jun 20, 2001·FEBS Letters·K Kolmodin, J Aqvist
Sep 14, 2001·Antioxidants & Redox Signaling·K A WebsterN H Bishopric
Sep 14, 2001·Antioxidants & Redox Signaling·D E WilcoxY Xu
Sep 14, 2001·Antioxidants & Redox Signaling·K D Kröncke
Sep 14, 2001·Antioxidants & Redox Signaling·P Hainaut, K Mann
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K D Kröncke
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Lichtlen, W Schaffner
Feb 6, 2002·Archives of Biochemistry and Biophysics·Elena A OstrakhovitchLars-Oliver Klotz
Jan 18, 2002·The Journal of Biological Chemistry·Klaus-Dietrich KrönckeHelmut Sies
Feb 8, 2002·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·D Beyersmann, H Haase
May 22, 2002·Neurochemistry International·Vemuganti L Raghavendra Rao
May 30, 2002·Biological Chemistry·Lars-Oliver Klotz
Sep 6, 2002·The Journal of Biological Chemistry·Irina KorichnevaUlrich Hammerling
Dec 31, 2002·Brain Research. Brain Research Reviews·Math P Cuajungco, Kyle Y Fagét
Jan 16, 2003·Nucleic Acids Research·S Sri KrishnaNick V Grishin
Mar 5, 2003·Journal of Cell Science·Bradley W Doble, James R Woodgett
Apr 1, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lars-Oliver KlotzHelmut Sies
Apr 1, 2003·IUBMB Life·Jacqueline M Matthews, Margaret Sunde
Apr 3, 2003·Molecular & Cellular Proteomics : MCP·Teresa KuncewiczBruce C Kone
May 14, 2003·The Journal of Biological Chemistry·Weidong WuAndrew J Ghio
Sep 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Andreas Barthel, Dieter Schmoll
Sep 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Weidong WuLee M Graves
May 1, 1965·The American Journal of Physiology·J Z RUTMANP GEORGE
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daniela U SpahlKlaus-D Kröncke
Dec 13, 2003·Biological Chemistry·Klaus-Dietrich Kröncke
Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Christopher J FredericksonMath P Cuajungco
Mar 24, 2004·Biochemistry·Wolfgang Maret
May 26, 2004·Biochemical and Biophysical Research Communications·Alexander A MakarovRonald T Raines
Sep 30, 2004·Free Radical Research·Stefan M SchiekeLars-Oliver Klotz
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yumin ZhangPaul A Rosenberg

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Citations

May 15, 2013·Molecular Neurobiology·María Rodríguez-Muñoz, Javier Garzón
Jan 22, 2011·Metallomics : Integrated Biometal Science·Susana M QuintalNicholas P Farrell
Sep 29, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Jamie L MichalekSarah L J Michel
Dec 14, 2011·The Journal of Biological Chemistry·Stefano M Marino, Vadim N Gladyshev
Feb 4, 2009·Antioxidants & Redox Signaling·Peep Palumaa
Jul 29, 2009·Antioxidants & Redox Signaling·Merridee A WoutersNaomi L Haworth
Jun 24, 2010·Antioxidants & Redox Signaling·Meika Foster, Samir Samman
Jul 16, 2010·Antioxidants & Redox Signaling·Peter L J de KeizerTobias B Dansen
Mar 12, 2011·Antioxidants & Redox Signaling·Valerio Chiurchiù, Mauro Maccarrone
Sep 4, 2010·Antioxidants & Redox Signaling·Stefano M Marino, Vadim N Gladyshev
Mar 23, 2012·Antioxidants & Redox Signaling·Shradha PrabhulkarChen-Zhong Li
Jul 4, 2012·Antioxidants & Redox Signaling·Goedele RoosJoris Messens
Jun 26, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wei ZhongZhanxiang Zhou
Jan 10, 2014·International Journal of Nanomedicine·Inès AzzouzHafedh Abdelmelek
Mar 26, 2014·Chemical Reviews·Fangting YuVincent L Pecoraro
Feb 19, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ingrit HamannLars-Oliver Klotz
Aug 22, 2009·Redox Report : Communications in Free Radical Research·Anna Eckers, Lars-Oliver Klotz
Feb 16, 2016·Journal of Inorganic Biochemistry·Patricia B Lutz, Craig A Bayse
Sep 8, 2009·Free Radical Biology & Medicine·Miriam M Cortese-KrottChristoph V Suschek
Nov 5, 2011·Chemistry : a European Journal·Emilie BourlèsOlivier Sénèque
Apr 21, 2016·Archives of Biochemistry and Biophysics·Bodo SpeckmannLars-Oliver Klotz
Feb 18, 2015·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Hsunhui YangLouise Lanoue
Sep 11, 2012·Free Radical Biology & Medicine·Patricia I Oteiza
May 23, 2012·Islets·Francisco J BedoyaJuan R Tejedo
Oct 4, 2012·Free Radical Biology & Medicine·Naomi L CookMichael J Davies
Feb 18, 2015·Trends in Immunology·Christian Bogdan
Aug 23, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David I PattisonMichael J Davies
Nov 26, 2013·Inorganic Chemistry·Sonia Antony, Craig A Bayse
Mar 19, 2013·International Journal of Molecular Sciences·Branislav Ruttkay-NedeckyRene Kizek
Dec 30, 2009·Journal of Cellular Physiology·Elvis PirevKlaus D Kröncke
Apr 27, 2013·Nature Reviews. Immunology·Carl Nathan, Amy Cunningham-Bussel
Oct 21, 2014·Metallomics : Integrated Biometal Science·A Gerard Daniel, Nicholas P Farrell
Jun 13, 2015·The Journal of Biological Chemistry·Xixi ZhouLaurie G Hudson
May 30, 2020·Zeitschrift für Gerontologie und Geriatrie·Holger Steinbrenner, Lars-Oliver Klotz
Jul 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne BriegerHajo Haase
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wei ZhongZhanxiang Zhou
Jan 11, 2020·Angewandte Chemie·Jin HeDavid Avnir

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