Zinc homeostasis plays an important role in the prevention of obesity-induced cardiac inflammation, remodeling and dysfunction.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Haina Zhang, Lu Cai

Abstract

Obesity often leads to cardiovascular diseases, such as obesity-related cardiac hypertrophy (ORCH), due to chronic cardiac inflammation. Zinc is structurally and functionally essential for many transcription factors, therefore it not only has anti-inflammatory and anti-oxidative stress functions, but also has insulin-like function, however, its role in the development of obesity-associated cardiac pathogenesis and the potentially underlying mechanism(s) remains unclear. This review aims to summarize the available evidence on the role of zinc homeostasis in the prevention of ORCH. It was recently reported that when four-week old mice were fed either high fat diet (HFD) or normal diet containing deficient, adequate or supplemented zinc, HFD induced obesity and ORCH along with increased phosphorylation of p38 MAPK and increased expression of B-cell lymphoma/ leukemia 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These effects were further aggravated by zinc deficiency and significantly alleviated by zinc supplementation. Mechanistically administration of a p38 MAPK specific inhibitor in HFD-fed mice for 3 months did not affect HFD-induced obesity and increased expression of BCL10 and CARD9, but completely abol...Continue Reading

References

Aug 1, 1980·Diabetes·L Coulston, P Dandona
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·E MoltchanovaUNKNOWN Finnish Childhood Diabetes Registry Group
Sep 21, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yusuke AdachiHiromu Sakurai
Sep 17, 2005·The Journal of Pharmacology and Experimental Therapeutics·Zoltán GiriczPéter Ferdinandy
May 22, 2007·Nature Immunology·Marco Colonna
Oct 6, 2010·Pediatric Diabetes·Ulf SamuelssonJohnny Ludvigsson
Jan 12, 2011·Annual Review of Immunology·Margaret F Gregor, Gökhan S Hotamisligil
Feb 7, 2013·Frontiers of Medicine·Xiao MiaoLu Cai
Jun 9, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ioannis AlexanianGerasimos Filippatos
Sep 4, 2014·Hypertension·Lajos MarkóDominik N Müller
Sep 10, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ananda S Prasad
Mar 7, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Sunil Kumar KansalSandeep Goyal
Feb 24, 2016·Journal of Molecular and Cellular Cardiology·Li CaoGuanglong He
Dec 7, 2016·Drug Design, Development and Therapy·Matthew R PetersonGuanglong He
Jan 4, 2017·The Journal of Clinical Investigation·Alan R Saltiel, Jerrold M Olefsky
Jun 7, 2017·Biological Trace Element Research·Mohammad Tariqur Rahman, Muhammad Manjurul Karim
Aug 16, 2017·Biological Trace Element Research·Abdulkerim Kasim BaltaciRasim Mogulkoc
Jan 21, 2018·Cell Death & Disease·Xiaoming ZhongZhiwen Yang
Feb 8, 2018·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Weixia SunLu Cai
Feb 9, 2018·International Journal of Molecular Sciences·Ayako Fukunaka, Yoshio Fujitani
Mar 31, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sumia A BageghniNeil A Turner
Jul 20, 2018·Frontiers in Immunology·Torben GehringDaniel Krappmann
Dec 15, 2018·European Cytokine Network·Jacek KarczewskiAgnieszka Dobrowolska
Jan 10, 2019·Free Radical Biology & Medicine·Wolfgang Maret
Feb 23, 2019·Integrated Pharmacy Research & Practice·Kevin Mc NamaraJohn Keith Jackson
Mar 3, 2019·Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·Muhammad Farooq
May 28, 2019·Nutrients·Daniela Costa-VieiraMaria João Martins
Aug 7, 2019·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Malka YahalomYoav Turgeman

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.