Zinc, immune plasticity, aging, and successful aging: role of metallothionein

Annals of the New York Academy of Sciences
Eugenio MocchegianiMarco Malavolta

Abstract

The capacity of the remodeling immune responses during stress (immune plasticity) is fundamental to reach successful aging. We herein report two pivotal models to demonstrate the relevance of the immune plasticity in aging and successful aging. One model is represented by the circadian rhythms of immune responses; the other one is the immune responses during partial hepatectomy/liver regeneration (pHx). The latter is suggestive because it mimics the immunosenescence and chronic inflammation 48 hours after partial hepatectomy in the young through the continuous production of IL-6, which is the main cause of immune plasticity lack in aging. The constant production of IL-6 leads to abnormal increments of zinc-bound metallothionein (MT), which is, in turn, unable in zinc release in aging. As a consequence, low zinc ion bioavailability appears for thymic and extrathymic immune efficiency, in particular, of liver NKT cells bearing TCR gd. The remodeling during the circadian cycle and during pHx of zinc-bound MT confers the immune plasticity of liver NKT gamma delta cells and NK cells in young and very old age, not in old age. Therefore, zinc-bound MT homeostasis is crucial in conferring liver immune plasticity with subsequent success...Continue Reading

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Citations

Sep 12, 2006·Biogerontology·Mehmet Alper ArslanCsaba Soti
May 2, 2009·Journal of Clinical Immunology·Eugenio MocchegianiMarco Malavolta
Sep 17, 2010·Biological Trace Element Research·Marin TotaBiserka Radošević-Stašić
Oct 14, 2008·Genes & Nutrition·Eugenio Mocchegiani, Marco Malavolta
May 19, 2006·Rejuvenation Research·Eugenio MocchegianiMarco Malavolta
Apr 11, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Catia CiprianoEugenio Mocchegiani
Oct 2, 2007·Immunity & Ageing : I & a·Eugenio MocchegianiMarco Malavolta
Oct 6, 2007·Stem Cell Reviews·S M Chambers, M A Goodell
Mar 16, 2007·Current Medical Research and Opinion·Stella S DaskalopoulouChristos D Liapis
Oct 12, 2010·Ageing Research Reviews·William R Swindell
May 11, 2005·Immunological Reviews·Dennis D Taub, Dan L Longo
Nov 14, 2006·International Journal of Cardiology·Robertina GiacconiEugenio Mocchegiani
May 11, 2005·World Journal of Gastroenterology : WJG·Ping JiangChao-Shu Tang
Sep 26, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Marco MalavoltaEugenio Mocchegiani
Dec 15, 2010·Biogerontology·Patrizio Odetti, Ettore Bergamini
May 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olga M PenaRobert E W Hancock
May 18, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Tingwen GeLu Cai
Nov 17, 2020·Frontiers in Immunology·John P DriverJürgen A Richt
Oct 13, 2006·Experimental Gerontology·Eugenio MocchegianiMarco Malavolta

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