PMID: 8582784Sep 1, 1995Paper

Zinc induces thymulin secretion from human thymic epithelial cells in vitro and augments splenocyte and thymocyte responses in vivo

International Journal of Immunopharmacology
A SahaJ W Hadden

Abstract

Zinc is incorporated into zinc-thymulin by the thymus and in this form is a critical hormonal regulator of cellular immunity. In the absence of serum, zinc induces human thymic epithelial cells (TEC) to secrete a factor which promotes the expansion of interleukin-2 (IL-2) receptor positive human peripheral blood lymphocytes in response to a low dose of phytohemagglutinin (PHA). This factor is removed by antithymulin antisera plus filtration and is thus presumed to be zinc-thymulin. Intraperitoneal treatment of hydrocortisone treated aged mice with zinc-thymulin (100 ng/day x 5) resulted in mild augmentation of splenocyte but not thymocyte responses in vitro to IL-1, IL-2, and natural cytokine mixture (NCM) and to PHA and concanavalin A (Con A) (average increase 40%). Like zinc-thymulin treatment, oral ingestion of zinc (72 micrograms/day x 5) resulted in augmentation of splenocyte IL responses; in contrast, it augmented thymocyte responses to all stimuli (average increase 100%). These preliminary experiments indicate that treatment with zinc may have immunotherapeutic relevance, particularly in the aged and stressed organism.

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Citations

Jul 4, 2008·Inflammopharmacology·F García-TamayoL I Terrazas-Valdés
Sep 1, 1995·International Journal of Immunopharmacology·J W Hadden
Sep 1, 1995·International Journal of Immunopharmacology·E Mocchegiani, N Fabris
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Jan 12, 1999·Mechanisms of Ageing and Development·E MocchegianiR Giacconi
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Nov 1, 2001·Developmental and Comparative Immunology·Daniel A OrringerJames A Marsh
Jul 16, 2003·International Immunopharmacology·Emma L VerasteguiJohn Hadden
Jul 16, 2003·International Immunopharmacology·K MasekJ W Hadden
Jul 16, 2003·International Immunopharmacology·J HaddenE Hadden
Jul 16, 2003·International Immunopharmacology·John W Hadden
Jan 11, 2000·The Proceedings of the Nutrition Society·L Rink, P Gabriel
Aug 18, 2001·The British Journal of Nutrition·P Bhaskaram
Jun 18, 1998·Annals of the New York Academy of Sciences·J W Hadden
Dec 18, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·B Obmińska-DomoradzkaJ Debowy
Aug 30, 2014·Chemico-biological Interactions·Eri FukunagaYasuo Oyama
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Apr 5, 2003·Immunopharmacology and Immunotoxicology·Nadzieja Drela, Izabela Ześko
Sep 18, 2012·Metallomics : Integrated Biometal Science·Doha DaaboulLothar Rink

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