Zinc ion as modulator effects on excitability and synaptic transmission in hippocampal CA1 neurons in Wistar rats

Neuroscience Research
Yutao TianTao Zhang

Abstract

Zinc is one of trace elements that play essential roles in several cell functions, and is unquestionably important to the normal health and function of the central nervous system. Growing evidence suggests that Zn(2+) can become a pathogenic agent in certain neurological disease states, such as ischemia, seizures, and trauma. The main role of the Zn(2+) may serve as an endogenous neuromodulator in the brain. In the present study, we used the electrophysiology method to investigate the effects of Zn(2+) on the excitability of hippocampus CA1 region. Our results have demonstrated that the Zn(2+) activates the Wistar rat hippocampal CA1 region network by significantly enhancing the spike rate of the spontaneous firing. In addition, Zn(2+) can increase the intrinsic membrane excitability by enhancing the firing rate and half-width of the evoked action potential. Meanwhile, our results also indicate that Zn(2+) can effectively inhibit voltage-dependent potassium currents (both transient outward potassium currents and delayed rectifier potassium currents). On the other hand, Zn(2+) also inhibits excitatory neurotransmitter release by decreasing the inter-event interval and the total charge transfer of the excitatory postsynaptic curr...Continue Reading

References

Aug 29, 1983·Brain Research·C J FredericksonJ B Kirkpatrick
Apr 19, 1984·Nature·S Y Assaf, S H Chung
Apr 19, 1984·Nature·G A HowellC J Frederickson
Oct 1, 1996·The European Journal of Neuroscience·M MartinaE Cherubini
Oct 30, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·C R JanC J Tseng
Oct 26, 2000·Trends in Pharmacological Sciences·J H WeissJ Y Koh
Jan 6, 2004·Journal of Neuroscience Research·Atsushi TakedaNaoto Oku
Mar 12, 2004·Epilepsy Research·Atsushi TakedaNaoto Oku
Jul 6, 2004·The European Journal of Neuroscience·Stéphanie DaumasJean-Michel Lassalle
Oct 13, 2004·Brain Research·M E Quinta-FerreiraJ C Dionísio
May 14, 2005·Nature Reviews. Neuroscience·Christopher J FredericksonAshley I Bush
Dec 13, 2005·Journal of Neuroscience Research·Akira MinamiAtsushi Takeda
Oct 28, 2006·Neurochemistry International·Atsushi TakedaNaoto Oku
Aug 8, 2007·Journal of Neuroscience Research·Atsushi TakedaNaoto Oku

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Citations

Jan 5, 2011·International Journal of Alzheimer's Disease·Nicole T WattNigel M Hooper
Jan 9, 2014·Somatosensory & Motor Research·Qizong YangJoshua C Brumberg
Jan 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Neha Singla, D K Dhawan
Nov 1, 2016·Journal of Neuroscience Research·Xin-Yi ChenYi-Feng Du
Nov 17, 2017·The Journal of Pharmacology and Experimental Therapeutics·Shu-Hui Chuang, Doodipala Samba Reddy
Apr 17, 2020·Chemical Communications : Chem Comm·Madhuparna RoySomdatta Ghosh Dey

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