PMID: 2484429Jan 1, 1989Paper

Zinc, iron, vitamin E, and erythrocyte stability in the rat

Biological Trace Element Research
I R RecordI E Dreosti

Abstract

Previous studies have shown that deficiencies of zinc and vitamin E, as well as iron excess, contribute to peroxidative damage in several tissues in vivo. The present study reports on the sensitivity of red blood cells from young rats exposed to individual or concurrent imbalances of these three nutrients. For 21 d, rats were fed diets that were either deficient or replete in zinc and with or without excess iron or replete or deficient in vitamin E. When red blood cells from these rats were incubated in vitro, erythrocyte hemolysis, lipid peroxidation (assessed by MDA production), and hemoglobin degradation (assessed by alanine release), did not significantly increase unless vitamin E had been omitted from the diet. These results imply that either adequate tightly-bound zinc exists within the zinc-deficient cell to protect it from oxidative damage, or that other antioxidant defense mechanisms (including vitamin E) present within the plasma membrane and cytosol are sufficient to protect the cell from the otherwise damaging effects of zinc deficiency and/or iron excess.

References

Feb 1, 1987·The Proceedings of the Nutrition Society·R L Willson
Nov 1, 1987·The Journal of Nutrition·B L O'DellP G Reeves
Jun 1, 1986·Teratology·I R RecordS J Manuel
Jan 1, 1980·Annals of the New York Academy of Sciences·L J Machlin, E Gabriel
Jan 1, 1982·Annals of the New York Academy of Sciences·S J Gross, S A Landaw
Mar 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·W J BettgerB L O'Dell
Dec 1, 1987·Biological Trace Element Research·I E Dreosti, E J Partick

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