Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway

Environmental Pollution
Jia-Yi ZhouXiu-Qi Wang

Abstract

The micronutrient, zinc, plays a vital role in modulating cellular signaling recognition and enhancing intestinal barrier function. However, the precise mechanisms underlying the zinc regulation of intestinal stem cell (ISC) renewal and regeneration ability, which drive intestinal epithelial turnover to maintain the intestinal barrier, under physiological and pathological conditions are unknown. In this study, we used in vivo mouse plus ex vivo enteroid model to investigate thoroughly the protection efficacy of zinc L-aspartate (Zn-Asp) on intestinal mucosal integrity exposed to deoxynivalenol (DON). The results showed that 10 rather than 20 mg/kg body weight (BW) Zn-Asp (calculation in zinc) significantly increased the jejunum mass and ameliorated mucosa injury caused by 2 mg/kg BW DON treatment, including improvement of the intestinal morphology and barrier, as well as enteroid-forming and -budding efficiency, which was expanded from crypt cells isolated from jejunum of mice in each group. The repair process stimulated by Zn-Asp was also accompanied by increased fluorescence signal intensity of KRT20 and Villin; increased numbers of MUC2+, CAG+, LYZ+, BrdU+ and Ki67+ cells in mouse jejunum; and protein expression of Ki67 and ...Continue Reading

References

Mar 15, 2005·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·James J Pestka, Alexa T Smolinski
Jun 20, 2008·The Journal of Surgical Research·Hasan TürütSecil Simsek Imrek
Aug 22, 2008·The Journal of Nutrition·Alberto FinamoreElena Mengheri
May 27, 2009·Experimental Cell Research·Yuan Li, Wolfgang Maret
Dec 28, 2010·European Journal of Pharmacology·Nageswaran SivalingamMolly Jacob
Sep 13, 2012·The Journal of Nutritional Biochemistry·Giulia RanaldiChiara Murgia
Jan 16, 2013·Advances in Nutrition·Wolfgang Maret
Nov 2, 2013·Food Chemistry·Yelko Rodríguez-CarrascoJordi Mañes
Dec 18, 2013·Cell Stem Cell·Ciara MetcalfeFrederic J de Sauvage
Feb 9, 2017·Cellular and Molecular Gastroenterology and Hepatology·Abigail B PodanyShannon L Kelleher
Feb 15, 2017·The Journal of Nutritional Biochemistry·Yuxin ShaoBingkun Zhang
Mar 30, 2017·Antioxidants·Dilina do Nascimento MarreiroAna Raquel Soares de Oliveira
May 4, 2017·Cellular and Molecular Gastroenterology and Hepatology·Nicholas R SmithMelissa H Wong
Mar 31, 2018·International Journal of Molecular Sciences·Xiang-Guang LiXiu-Qi Wang
Aug 18, 2018·Experimental & Molecular Medicine·Chaithanya ChelakkotSung Ho Ryu
Nov 16, 2018·Nature Reviews. Gastroenterology & Hepatology·Helmuth Gehart, Hans Clevers
Jun 17, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jia-Yi ZhouXiu-Qi Wang

❮ Previous
Next ❯

Citations

Nov 18, 2020·Stem Cell Reviews and Reports·Shao-Jie LiangXiu-Qi Wang
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Li GaoJiaoyan Ren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.