Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage

JRSM Open
Harri Hemilä

Abstract

To compare the efficacy of zinc acetate lozenges with zinc gluconate lozenges in common cold treatment and to examine the dose-dependency of the effect. Meta-analysis. Placebo-controlled zinc lozenge trials, in which the zinc dose was > 75 mg/day. The pooled effect of zinc lozenges on common cold duration was calculated by using inverse-variance random-effects method. Seven randomised trials with 575 participants with naturally acquired common colds. Duration of the common cold. The mean common cold duration was 33% (95% CI 21% to 45%) shorter for the zinc groups of the seven included trials. Three trials that used lozenges composed of zinc acetate found that colds were shortened by 40% and four trials that used zinc gluconate by 28%. The difference between the two salts was not significant: 12 percentage points (95% CI: -12 to + 36). Five trials used zinc doses of 80-92 mg/day, common cold duration was reduced by 33%, and two trials used zinc doses of 192-207 mg/day and found an effect of 35%. The difference between the high-dose and low-dose zinc trials was not significant: 2 percentage points (95% CI: -29 to + 32). Properly composed zinc gluconate lozenges may be as effective as zinc acetate lozenges. There is no evidence th...Continue Reading

References

Jun 1, 1992·The Journal of International Medical Research·J C GodfreyN J Godfrey
May 1, 1989·Antimicrobial Agents and Chemotherapy·D S SmithA Magner
Jan 1, 1987·Journal of Chronic Diseases·B M Farr, J M Gwaltney
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·J C Godfrey
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·G A Eby
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·R B Martin
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·G A EbyW W Halcomb
Jun 27, 1998·JAMA : the Journal of the American Medical Association·M L MackninE Wald
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R B Turner, W E Cetnarowski
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A Eby
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 27, 2004·Bioscience Reports·George A Eby
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J CarusoJack M Gwaltney
Nov 13, 2009·Medical Hypotheses·George A Eby
Jul 20, 2011·The Open Respiratory Medicine Journal·Harri Hemilä
Mar 23, 2012·International Journal of Dermatology·Joel T M BamfordBrian P Johnson
May 9, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Michelle ScienceMark Loeb
Jul 7, 2012·Journal of Pain & Palliative Care Pharmacotherapy·Laurel LyckholmRobert I Henkin
Jul 6, 2016·British Journal of Clinical Pharmacology·Harri HemiläAnanda Prasad

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Citations

Feb 6, 2019·MMW Fortschritte der Medizin·Gustav Dobos
Oct 12, 2018·BMJ : British Medical Journal·Mieke L van DrielAn De Sutter
Mar 30, 2020·Journal of the Chinese Medical Association : JCMA·Nasir Ali Afsar
May 13, 2020·The Annals of Pharmacotherapy·Kathleen K AdamsDiana M Sobieraj
Aug 27, 2019·Frontiers in Immunology·Andrew J ForgieBenjamin P Willing
Apr 23, 2020·International Journal of Molecular Medicine·Anatoly V SkalnyAlexey A Tinkov
Aug 6, 2020·Frontiers in Immunology·Inga WesselsLothar Rink
Sep 11, 2020·Disaster Medicine and Public Health Preparedness·Rima MoghniehAbdul Rahman Bizri
Dec 16, 2020·Journal of Intensive Care Medicine·Pierre KoryPaul E Marik
Jan 14, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Muhammad Torequl IslamJavad Sharifi-Rad
Jan 22, 2021·Journal of Medical Virology·Eric Finzi, Allan Harrington
Feb 12, 2021·Nutrition Reviews·Saeed AkhtarZulfiqar A Bhutta
Nov 25, 2020·BMJ Nutrition, Prevention & Health·Philip C Calder
Mar 21, 2021·British Journal of Clinical Pharmacology·Vidyasagar ChinniOneel Patel
Jun 9, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Muhammad Osama YaseenTalib Hussain
Jun 1, 2021·Sustainable Cities and Society·Ferial GhaemiMassimiliano Ferrara
Jun 15, 2021·Journal of the American Pharmacists Association : JAPhA·Harri Hemilä, Elizabeth Chalker
Aug 10, 2021·Biological Trace Element Research·Fatemeh SadeghsoltaniMostafa Vaghari-Tabari

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