PMID: 6413772Jan 1, 1983Paper

Zinc metabolism in animals: pathology, immunology and genetics

Journal of Inherited Metabolic Disease
J K Chesters

Abstract

Deficiency of dietary Zn rapidly reduces both appetite and growth, the latter effect being apparently caused by a failure of cell replication. Diagnosis of presymptomatic Zn deficiency depends largely on estimation of plasma Zn concentration but is complicated by reductions of it during a range of stressful conditions. In the latter cases, the decrease in plasma Zn concentration does not appear to be associated with inadequate Zn intake. Only two genetic defects of Zn metabolism are known in animals. One is associated with lethally inadequate concentrations of Zn in the milk of mice, the other with the A46 trait in Friesian cattle. A46 is a recessively inherited defect of Zn absorption which is lethal in the absence of major Zn supplementation of the diet. The characteristics of the disease are very similar to those of acrodermatitis enteropathica in man.

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Citations

Jan 1, 1983·Journal of Inherited Metabolic Disease·P J Aggett, N T Davies
Jan 1, 1983·Journal of Inherited Metabolic Disease·P J Aggett
Dec 4, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Shakhenabat KasanaWolfgang Maret
May 29, 2012·The Veterinary Journal·Peter J White, Peter A Windsor
Aug 13, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Birgit PuschnerMark C Thurmond
Jan 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M A MillerH S Gosser
Jun 13, 2003·The Journal of Biological Chemistry·Jodi Dufner-BeattieGlen K Andrews
Nov 13, 2003·The Journal of Biological Chemistry·Byung-Eun KimMichael J Petris
Oct 17, 2017·Journal of Animal Physiology and Animal Nutrition·L-T NeustädterC Ratert
Apr 21, 2018·Microbiology Spectrum·Christopher RensingSylvia Franke McDevitt

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