PMID: 11606802Oct 19, 2001Paper

Zinc-metallothionein levels are correlated with enhanced glucocorticoid responsiveness in mouse cells exposed to ZnCl(2), HgCl(2), and heat shock

Toxicological Sciences : an Official Journal of the Society of Toxicology
J M DeMoorJ Koropatnick

Abstract

Metallothioneins (MTs) are the major low molecular weight, zinc-binding proteins in mammalian cells. It has been hypothesized that they play a role in the function of zinc-dependent signal transduction proteins and transcription factors. We investigated the capacity of zinc and other metal ions and conditions to increase both Zn-associated MT levels and the receptiveness of cells to transcriptional activation mediated by the zinc-dependent glucocorticoid receptor (GR). We studied, in a GR-responsive mouse mammary-tumor cell line, the ability of dexamethasone (DEX) to stimulate transcription of a chloramphenicol acetyltransferase (CAT) gene controlled by a mouse mammary-tumor virus promoter. In cells pretreated with 20 to 100 microM ZnCl(2), DEX-induced CAT activity correlated with zinc-induced MT levels. However, 0.05 to 0.5 microM CdCl(2) had no effect on CAT activity, despite an increase in Cd-associated MT. Copper-associated MT was detected in cells treated with 20 microM CuCl(2,) but there was no change in the level of Zn-MT, nor was CAT activity altered in cells exposed to 5 to 20 microM CuCl(2). These results may reflect a functional difference between zinc-associated MT, and MT associated with other metals. Significantly...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 26, 1992·Molecular and Cellular Biochemistry·T HatayamaH Imahara
Jul 1, 1991·The Journal of Membrane Biology·T J Simons
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J ZengJ H Kägi
Jan 1, 1986·Annual Review of Biochemistry·D H Hamer
Jan 1, 1981·Journal of Cellular Physiology·M KarinH R Herschman
May 1, 1980·The Biochemical Journal·A O Udom, F O Brady
Sep 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·D C DuBoisW J Jusko
Jul 1, 1995·Neurochemistry International·B L Vallee
May 1, 1994·Journal of Inorganic Biochemistry·A PattanaikA J Kraker
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A MastersR D Palmiter
Jan 1, 1994·Toxicology and Applied Pharmacology·M E Leibbrandt, J Koropatnick
Aug 6, 1993·Science·T V O'Halloran
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J W BaumanC D Klaassen
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A E Michalska, K H Choo
Oct 1, 1993·Molecular and Cellular Biology·R I ScheinmanA S Baldwin
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·W MaretB L Vallee
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·E J KellyR D Palmiter
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L J JiangB L Vallee
May 16, 1998·The Journal of Nutrition·R J McMahon, R J Cousins
May 25, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·R BofillP Gonzàlez-Duarte

❮ Previous
Next ❯

Citations

Aug 27, 2013·Biological Trace Element Research·Liping TaoHui Shen
Dec 4, 2003·Mutation Research·Farzana HaqJames Koropatnick
Jun 1, 2010·Toxins·Jeanette I Webster Marketon, Esther M Sternberg
Dec 30, 2009·Journal of Cellular Physiology·Elvis PirevKlaus D Kröncke
Mar 23, 2011·Journal of Insect Physiology·Joanna Borowska, Elżbieta Pyza
Jun 10, 2017·International Journal of Molecular Sciences·Artur Krężel, Wolfgang Maret
Dec 21, 2006·Journal of Applied Toxicology : JAT·Jelena BrkljacićGordana Matić
Apr 17, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S DemuynckA Leprêtre
Mar 25, 2004·The Journal of Pharmacology and Experimental Therapeutics·Heather L ButcherJames Koropatnick
Sep 18, 2015·Journal of Biochemical and Molecular Toxicology·Yu ZhangWentao Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
R D Palmiter
Journal of Biochemical and Molecular Toxicology
Jelena BrkljacićGordana Matić
© 2021 Meta ULC. All rights reserved