Zinc Oxide Nanoparticles and Voltage-Gated Human Kv 11.1 Potassium Channels Interact through a Novel Mechanism

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Stefania Piscopo, Euan R Brown

Abstract

Membrane-nanoparticle interactions are important in determining the effects of manufactured nanomaterials on cell physiology and pathology. Here, silica, titanium, zinc, and magnesium oxide nanoparticles are screened against human hERG (Kv 11.1) voltage-gated potassium channels under a whole-cell voltage clamp. 10 µg mL-1 ZnO uniquely increases the amplitude of the steady-state current, decreases the rate of hERG current inactivation during steady-state depolarization, accelerates channel deactivation during resurgent tail currents, and shows no significant alteration of current activation rate or voltage dependence. In contrast, ZnCl2 causes increased current suppression with increasing concentration and fails to replicate the nanoparticle effect on decreasing inactivation. The results show a novel class of nanoparticle-biomembrane interaction involving channel gating rather than channel block, and have implications for the use of nanoparticles in biomedicine, drug delivery applications, and nanotoxicology.

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Citations

Aug 23, 2019·Nanotoxicology·Roberta GualdaniClaudio Sangregorio
Jul 11, 2019·British Journal of Pharmacology·Suhan YinLongquan Shao
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Isabel U Foreman-OrtizJoel A Pedersen
Nov 11, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hadi HematianBohuslav Rezek

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