Zinc oxide nanoparticles from Cyperus rotundus attenuates diabetic retinopathy by inhibiting NLRP3 inflammasome activation in STZ-induced diabetic rats.

Journal of Biochemical and Molecular Toxicology
Liwei ZhangHua Li

Abstract

Diabetic retinopathy (DRP) is a retinal disease caused by diabetes mellitus, which is categorized by microvascular lesions present in the retina such as vascular leakage, vascular proliferation, and retinal ischemia. The plan of the present study was to the synthesis of Cyperus rotundus-loaded zinc oxide nanoparticles (CR-ZnONPs) which was confirmed by the various characterization methods such as UV-vis spectroscopy, energy dispersive X-ray analysis, Fourier transform infrared, scanning electron microscope, and X-ray diffraction. Also, the effect of CR-ZnONPs on DRP-induced rats was determined by food intake, fasting blood glucose (FBG), HbA1c, insulin, retina thickness, inner nuclear layer (INL), outer nuclear layer (ONL) thickness, lipid peroxidation (LPO), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). Furthermore, the status of oxidative stress marker genes (heme oxygenase-1 [HO-1] and nuclear factor erythroid 2-related factor-2 [Nrf2]) and inflammatory marker (procaspase-1, cleaved-caspase-1, interleukin-1β [IL-1β], IL-18, and ASC) expressions were examined by using real-time polymerase chain reaction and Western blot analysis techniques. We noted that the synthesized CR-ZnONPs have a crystal...Continue Reading

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May 13, 2021·European Journal of Pharmacology·Abdullah Al MamunJian Xiao
Jul 7, 2021·Journal of Biomaterials Science. Polymer Edition·Rakesh Kumar PaulKaisar Raza

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