Zinc phosphate-based nanoparticles as a novel antibacterial agent: in vivo study on rats after dietary exposure

Journal of Animal Science and Biotechnology
Pavel HorkyKristyna Smerkova

Abstract

Development of new nanomaterials that inhibit or kill bacteria is an important and timely research topic. For example, financial losses due to infectious diseases, such as diarrhea, are a major concern in livestock productions around the world. Antimicrobial nanoparticles (NPs) represent a promising alternative to antibiotics and may lower antibiotic use and consequently spread of antibiotic resistance traits among bacteria, including pathogens. Four formulations of zinc nanoparticles (ZnA, ZnB, ZnC, and ZnD) based on phosphates with spherical (ZnA, ZnB) or irregular (ZnC, ZnD) morphology were prepared. The highest in vitro inhibitory effect of our NPs was observed against Staphylococcus aureus (inhibitory concentration values, IC50, ranged from 0.5 to 1.6 mmol/L), followed by Escherichia coli (IC50 0.8-1.5 mmol/L). In contrast, methicillin resistant S. aureus (IC50 1.2-4.7 mmol/L) was least affected and this was similar to inhibitory patterns of commercial ZnO-based NPs and ZnO. After the successful in vitro testing, the in vivo study with rats based on dietary supplementation with zinc NPs was conducted. Four groups of rats were treated by 2,000 mg Zn/kg diet of ZnA, ZnB, ZnC, and ZnD, for comparison two groups were supplemen...Continue Reading

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Citations

Jun 16, 2019·Animals : an Open Access Journal From MDPI·Pavel HorkyJiri Skladanka
Jun 13, 2020·Journal of Animal Science and Biotechnology·Silvia KociovaKristyna Smerkova
Oct 9, 2020·Biological Trace Element Research·Faria FatimaWaqar Ahmad Khan
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Syafiqah SaidinAbdullah Sharaf Saleh Al-Hammadi
May 1, 2021·International Journal of Molecular Sciences·Ingmar A J van HengelAmir A Zadpoor
May 27, 2021·Experimental Biology and Medicine·Deboleena KanjilalJ Patrick O'Connor

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Methods Mentioned

BETA
dynamic light scattering
MDA
Assay
PCA

Software Mentioned

SPSS Statistics
Ascent
STATISTICA

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