Zinc prevents sickness behavior induced by lipopolysaccharides after a stress challenge in rats

PloS One
Thiago B KirstenMaria M Bernardi

Abstract

Sickness behavior is considered part of the specific beneficial adaptive behavioral and neuroimmune changes that occur in individuals in response to infectious/inflammatory processes. However, in dangerous and stressful situations, sickness behavior should be momentarily abrogated to prioritize survival behaviors, such as fight or flight. Taking this assumption into account, we experimentally induced sickness behavior in rats using lipopolysaccharides (LPS), an endotoxin that mimics infection by gram-negative bacteria, and then exposed these rats to a restraint stress challenge. Zinc has been shown to play a regulatory role in the immune and nervous systems. Therefore, the objective of this study was to examine the effects of zinc treatment on the sickness response of stress-challenged rats. We evaluated 22-kHz ultrasonic vocalizations, open-field behavior, tumor necrosis factor α (TNF-α), corticosterone, and brain-derived neurotrophic factor (BDNF) plasma levels. LPS administration induced sickness behavior in rats compared to controls, i.e., decreases in the distance traveled, average velocity, rearing frequency, self-grooming, and number of vocalizations, as well as an increase in the plasma levels of TNF-α, compared with co...Continue Reading

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Citations

Nov 25, 2019·Veterinary Research Communications·Túlio R R MazucoThiago Berti Kirsten
Apr 23, 2019·Journal of Central Nervous System Disease·Divine C NwaforCandice M Brown
Sep 16, 2019·Behavioural Brain Research·Carolina Vieira CardosoEduardo Fernandes Bondan
Aug 24, 2021·Behavioural Brain Research·Nathaniel S RiegerJohn P Christianson

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Methods Mentioned

BETA
enzyme-linked immunosorbent

Software Mentioned

Ultravox
EthoVision

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