Zinc protection against cadmium-induced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
K PaksyP Lázár

Abstract

Adult female rats were treated subcutaneously (s.c.) with zinc chloride (ZnCl2, 10 or 20 mg kg-1 body weight, bw) four times during two ovarian cycles. The third injection was accompanied by cadmium chloride (CdCl2) administration sc (2.5, 5 and 10 mg kg-1 bw). The fourth zinc (Zn) treatment was followed by mating. ZnCl2 (20 mg kg-1) itself impaired fertility by 20%, while CdCl2 dose-dependently blocked the receptivity of female rats. In combination with 2.5 and 5 mg kg-1 CdCl2 the metal salts decreased fertility in an additive fashion, whereas at the highest CdCl2 dose (10 mg kg-1) a marked ameliorating effect of ZnCl2 (10 and 20 mg kg-1) on cadmium (Cd)-caused sterility was observed. In the pregnant animals apart from the higher Cd-induced blood progesterone levels and reduced body weight gain of dams, no significant treatment-related maternal and fetal effects could be observed. ZnCl2 (10 to 80 microM) and CdCl2 (10 to 80 microM) were added to the culture medium of ovarian granulosa cells. CdCl2 suppressed follicle-stimulating-hormone- (FSH-) and cAMP-stimulated progesterone accumulation. No protective effect of Zn against Cd-induced drop in progesterone production could be seen, while Zn by itself induced a significant incr...Continue Reading

Citations

Jan 13, 2010·Environmental Health Perspectives·Gaëlle AngenardGabriel Livera
Feb 1, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Xiaoping JingZhisheng Wang
Apr 27, 2017·Biological Trace Element Research·Anatoly V SkalnyYulia Kovas
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May 1, 2012·Reproduction, Fertility, and Development·Patrícia Carvalho GarciaOduvaldo Câmara Marques Pereira
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