PMID: 6979248Jan 1, 1980Paper

Zinc protoporphyrin, blood lead and clinical symptoms in two occupational groups with low-level exposure to lead

American Journal of Industrial Medicine
A FischbeinI J Selikoff

Abstract

The results of cross-sectional clinical field surveys of 45 cable manufacturing workers and 90 telephone cable splicers are presented. Despite the rare occurrence of clinically overt lead poisoning among these occupational groups, high prevalence of lead-associated central nervous system symptoms and gastrointestinal symptoms was found. Hierarchical log-linear models for multidimensional contingency tables were fitted to those data and indicate that there is a partial correlation between reported symptoms and zinc protoporphyrin: individuals with high zinc protoporphyrin levels were more likely to report symptoms than those with low levels. No significant partial association was found between symptoms and blood lead. Because of the intermittent lead exposure encountered in one of the populations, individuals were identified with "normal" blood lead levels associated with "elevated" zinc protoporphyrin concentrations, thus indicating the difference in the biological significance between indicators of lead absorption (blood lead) and of biological response tests (ZPP). Suggestion is made that both types of diagnostic tests be utilized in the medical surveillance of lead-exposed workers.

References

Apr 1, 1975·Archives of Environmental Health·A M SeppäläinenB Kock
Jul 14, 1978·International Archives of Occupational and Environmental Health·J A ValciukasI J Selikoff
Dec 1, 1979·Scandinavian Journal of Work, Environment & Health·S Hernberg, S Tola
Jun 30, 1977·International Archives of Occupational and Environmental Health·R L Zielhuis
Nov 1, 1977·Archives of Environmental Health·R LilisI J Selikoff

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Citations

Jan 1, 1982·International Archives of Occupational and Environmental Health·F Labrèche, A P'an
Feb 1, 1983·Bulletin of Environmental Contamination and Toxicology·A J VerlangieriJ C Kapeghian
Jan 1, 1986·Physiology & Behavior·W J EngellennerP J Donovick
Mar 1, 1985·The Science of the Total Environment·C GrasmickH Sarmini
May 15, 1991·The Science of the Total Environment·R CleymaetY Michotte
Jan 1, 1989·Social Science & Medicine·R D BaerS Davison
Jan 16, 1982·Lancet·J PatrickM Gillieson
Jan 16, 1982·Lancet·A Fischbein, J Wallace
Jul 1, 1996·Neurotoxicology and Teratology·B T Stollery
Nov 1, 1989·Neurotoxicology and Teratology·C M Regan
Dec 1, 1986·Journal of Applied Toxicology : JAT·B R HolleboneR Karwowska
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·M Karstadt, R Bobal
Jun 1, 1981·The Journal of Pediatrics·R YipA S Anderson
Mar 1, 1988·Human Toxicology·D S Ooi, S L Perkins
May 21, 1981·Nature·P Grandjean
Jan 1, 1985·American Journal of Industrial Medicine·L GlickmanI Weisman
Aug 1, 1997·Molecular and Chemical Neuropathology·L StruzyńskaU Rafałowska
Oct 1, 1996·Molecular and Chemical Neuropathology·B Dabrowska-BoutaU Rafałowska
Oct 24, 2006·Environmental Monitoring and Assessment·Qing-wei YangFang-yan Long
Apr 1, 1991·The Journal of Laryngology and Otology·N S TolleyH O Williams
Dec 1, 1994·Cellular and Molecular Neurobiology·L JabłońskaU Rafałowska
Mar 22, 2001·International Journal of Environmental Health Research·M LacasañaM Hernandez-Avila
Jul 9, 2004·Environmental Health Perspectives·Lourdes SchnaasEstela Perroni
Jan 1, 1991·British Journal of Neurosurgery·M S Eljamel, P M Foy
Jan 1, 1984·Critical Reviews in Toxicology·T Beritić
Oct 1, 1992·The Australian and New Zealand Journal of Surgery·B T Stewart, A H Kaye
Jan 1, 1989·American Journal of Industrial Medicine·C N OngK Saijoh
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·D L DavisM Schneiderman
Oct 1, 1989·British Journal of Industrial Medicine·B T StolleryW R Lee
Jan 1, 1984·International Archives of Occupational and Environmental Health·L GlickmanI Weisman
Sep 11, 2020·Biomedical Chromatography : BMC·Nathália R SantosJosé A Menezes-Filho

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