Abstract
Zinc protoporphyrin pretreatment protects against temporary focal ischemic brain injury in rats. However, it is not known whether the zinc or the protoporphyrin portion of zinc protoporphyrin has effects on focal cerebral ischemia. Hence, all three agents were compared with regard to infarct size and edema in a rat model of middle cerebral artery occlusion. Four groups of adult male Sprague-Dawley rats were subjected to 2 hours of temporary middle cerebral artery occlusion followed by 22 hours of reperfusion. Each group was pretreated 30 minutes before middle cerebral artery occlusion with 0.9% NaCl, and then three groups were given equimolar doses of zinc protoporphyrin, zinc chloride, or protoporphyrin, respectively. Regional cerebral blood flow in the ischemic cortex was monitored with a laser Doppler flowmeter. Cerebral infarct size, brain water content, and ion content were measured 24 hours after the onset of occlusion. Regional cerebral blood flow during middle cerebral artery occlusion was approximately 9.2% to 13% of baseline in all four groups. Brain water content in the infarcted zone after temporary focal ischemia in control, zinc protoporphyrin, zinc chloride, and protoporphyrin groups was 85.7%, 80.6%, 85.6%, and ...Continue Reading
References
Nov 1, 1992·Agents and Actions·H NagaiA Koda
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D MartzA L Betz
Jun 1, 1990·The Journal of Physiology·B D Winegar, J B Lansman
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U DirnaglW Pulsinelli
May 1, 1987·Science·S PetersD W Choi
Aug 13, 1987·Nature·G L Westbrook, M L Mayer
May 17, 1994·European Journal of Pharmacology·D Luo, S R Vincent
Nov 1, 1993·Trends in Pharmacological Sciences·Z I Bashir, J M Henley
May 17, 1996·Science·J Y KohD W Choi
Citations
Jan 30, 2004·Neuroscience Letters·Alireza P- ShabanzadehChen Xu Wang
Nov 14, 1998·Brain Research·J C SørensenB B Johansson
Aug 28, 2003·Neuropharmacology·N NakamichiN N Osborne
Jan 28, 2003·Neurochemistry International·Chun-Jung Chen, Su-Lan Liao
Mar 10, 2001·Progress in Neurobiology·M Ugarte, N N Osborne
May 22, 2003·Free Radical Biology & Medicine·Anya M Y LinC H J Yang
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·Y J ZhaoE F Domino
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·Y J ZhaoE F Domino
Apr 8, 1998·Annual Review of Neuroscience·D W Choi, J Y Koh
Dec 2, 2011·Journal of Neurophysiology·Isamu AibaC William Shuttleworth
Jul 12, 2007·Molecular Medicine·Sherri L Galasso, Richard H Dyck
Sep 19, 2009·Nutritional Neuroscience·Roberto AquilaniSimona Viglio
Jan 7, 2000·Biochemical and Biophysical Research Communications·M ScharteJ Meyer
May 5, 2005·Nutrition Reviews·Cathy W Levenson
Apr 9, 2013·Neuroscience·I Pérez-de-PuigA M Planas
Jan 25, 2003·Hippocampus·Maren BüchnerMatthias W Riepe
Feb 6, 2007·The Journal of Surgical Research·Christian EipelBrigitte Vollmar
Apr 5, 2003·Journal of Neurochemistry·Chun-Jung Chen, Su-Lan Liao
May 4, 2011·Journal of Neuroscience Research·Brad A SutherlandIan Appleton
Sep 3, 2013·Oxidative Medicine and Cellular Longevity·Victor Manuel Blanco-AlvarezBertha Alicia Leon-Chavez
May 30, 1998·Experimental Neurology·B E DwyerR N Nishimura
Apr 12, 2001·Toxicology and Applied Pharmacology·J L KangV Castranova
Jul 27, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshinori KotaniHideaki Hara
May 19, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Roberto AquilaniFederica Boschi
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jihee Lee KangVincent Castranova
Mar 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Min-Liang Si, Tony Jer-Fu Lee
Jul 17, 1999·The American Journal of Physiology·L YangN G Abraham