Zinc Resistance within Swine-Associated Methicillin-Resistant Staphylococcus aureus Isolates in the United States Is Associated with Multilocus Sequence Type Lineage

Applied and Environmental Microbiology
Samantha J HauTracy L Nicholson

Abstract

Zinc resistance in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) sequence type 398 (ST398) is primarily mediated by the czrC gene colocated with the mecA gene, encoding methicillin resistance, within the type V staphylococcal cassette chromosome mec (SCCmec) element. Because czrC and mecA are located within the same mobile genetic element, it has been suggested that the use of zinc in feed as an antidiarrheal agent has the potential to contribute to the emergence and spread of methicillin-resistant S. aureus (MRSA) in swine, through increased selection pressure to maintain the SCCmec element in isolates obtained from pigs. In this study, we report the prevalence of the czrC gene and phenotypic zinc resistance in U.S. swine-associated LA-MRSA ST5 isolates, MRSA ST5 isolates from humans with no swine contact, and U.S. swine-associated LA-MRSA ST398 isolates. We demonstrated that the prevalence of zinc resistance in U.S. swine-associated LA-MRSA ST5 isolates was significantly lower than the prevalence of zinc resistance in MRSA ST5 isolates from humans with no swine contact and swine-associated LA-MRSA ST398 isolates, as well as prevalences from previous reports describing zinc resistance in other LA-M...Continue Reading

References

Aug 1, 1972·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·L A DevrieseL Fameree
Nov 1, 2002·Journal of Clinical Microbiology·Keiko OkumaKeiichi Hiramatsu
Feb 21, 2006·Emerging Infectious Diseases·Andreas VossMireille Wulf
Mar 21, 2007·Veterinary Microbiology·A J de NeelingX W Huijsdens
Nov 21, 2007·Veterinary Microbiology·T KhannaJ S Weese
Jul 1, 2008·Trends in Microbiology·Binh An Diep, Michael Otto
Sep 5, 2009·The Journal of Clinical Investigation·Frank R DeLeo, Henry F Chambers
Oct 12, 2010·Vector Borne and Zoonotic Diseases·Tara C Smith, Nicole Pearson
Apr 12, 2012·Clinical Microbiology Reviews·Sebastian J van HalIain B Gosbell
Sep 14, 2012·Journal of Clinical Microbiology·Bayleyegn MollaWondwossen A Gebreyes
Oct 10, 2012·Current Opinion in Microbiology·José R MediavillaBarry N Kreiswirth
Jun 4, 2013·Journal of Food Protection·Birgit Lassok, Bernd-Alois Tenhagen
Feb 11, 2015·Applied and Environmental Microbiology·Mackenzie Jonathan SlifierzJ Scott Weese
Oct 23, 2015·The Journal of Antimicrobial Chemotherapy·E van DuijkerenA van de Giessen
Apr 1, 2017·Genome Announcements·Samantha J HauTracy L Nicholson

❮ Previous
Next ❯

Citations

Feb 26, 2019·Journal of Animal Science and Biotechnology·Pavel HorkyKristyna Smerkova
Dec 7, 2018·Frontiers in Cellular and Infection Microbiology·John K CraneMark D Sutton
Jul 14, 2020·The Journal of Veterinary Medical Science·Yoshimasa SasakiYutaka Tamura
Jun 12, 2020·Immunological Investigations·John K Crane
Jan 13, 2021·The Journal of Veterinary Medical Science·Yoshimasa SasakiTetsuo Asai
Feb 12, 2021·Clinical Microbiology Reviews·Soyoun Park, Jennifer Ronholm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cellulitis

Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.