PMID: 2484524Jan 1, 1988Paper

Zinc-selenium interaction in the rat

Biological Trace Element Research
J ChmielnickaE A Brzeźnicka

Abstract

Retention, dynamics of 75Se and 65Zn distribution, and elimination were studied in rats after separate or joint single doses of these metals. White female Wistar rats were divided into four groups (fifteen rats each). Group I received Na2(75)SeO3 (0.1 mg Se/kg i.g.), group II received Na2(75)SeO3 + ZnCl2 (5 mg Zn/kg s.c.), group III received 65ZnCl2, and group IV received 65ZnCl2 + Na2SeO3. The zinc and selenium contents in the tissues were estimated during 120 h after administration; excretion in urine and feces of animals was determined throughout the experiment. Combined administration of zinc and selenium resulted in an enhanced selenium retention in the brain, spleen, kidneys, blood, lungs, and heart. A selenium-induced increase in the concentration of zinc was noted in the bowels, blood, liver, kidneys, spleen, brain, and lungs. The effects of the zinc/selenium interaction were visible especially in the lowered level of excretion of these elements. Zinc induced a decrease in the excretion of selenium in urine, with no concomitant changes in the excretion in feces. However, a visible decrease in the excretion of zinc in the feces was observed in the presence of selenium. The present results indicate an occurrence of clear-...Continue Reading

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·A S Prasad
Mar 1, 1979·The American Journal of Clinical Nutrition·R L AamodtR I Henkin
Jun 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M P Waalkes, C D Klaassen
May 1, 1981·British Journal of Industrial Medicine·J ChmielnickaJ A Szymańska
Nov 1, 1980·Critical Reviews in Toxicology·L Magos, M Webb
Jan 1, 1982·Drug Metabolism Reviews·B A BoppJ W Kesterson

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Citations

Jan 1, 1993·Biological Trace Element Research·J ChmielnickaA Korycka
Feb 13, 2008·Biological Trace Element Research·Rabiha SeboussiBahaa Mahjoub
Jun 3, 2009·Biological Trace Element Research·Rabiha SeboussiAhmed Elkhouly
Aug 27, 2011·Biological Trace Element Research·Ying WangJing-Yu Wang
Jun 17, 2011·Journal of the American College of Nutrition·Karl T WeberWilliam L Hickerson
Mar 15, 2011·European Heart Journal·Brian J BorkowskiKarl T Weber
Mar 14, 2014·Biological Trace Element Research·María José Monedero-PrietoPedro Abreu-González
Jul 13, 2011·The American Journal of the Medical Sciences·Antwon D RobinsonKarl T Weber
Aug 1, 1993·Medical Hypotheses·R S BedwalR S Mathur
Jun 1, 1996·Zeitschrift für Ernährungswissenschaft·G RimbachK Krämer

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