Zinc signaling and epilepsy

Pharmacology & Therapeutics
Urszula DoboszewskaPiotr Wlaź

Abstract

Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition underlies seizures. However, the relationship between zinc signaling and seizures/epilepsy is complex as both extracellular and intracellular zinc may produce either protective or detrimental effects. This review provides an overview of preclinical/behavioral, functional and molecular studies, as well as clinical data on the involvement of zinc in the pathophysiology and treatment of seizures/epilepsy. Furthermore, the potential of targeting elements associated with zinc signaling or homeostasis and zinc levels as a therapeutic strategy for epilepsy is discussed.

Citations

May 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nadine WiesmannJuergen Brieger
Jul 17, 2020·British Journal of Pharmacology·Urszula DoboszewskaKatarzyna Młyniec
Sep 30, 2020·Pharmaceuticals·Pooyan KhalighinejadA Dean Sherry
Dec 19, 2020·International Journal of Molecular Sciences·Jacek BajHanna Karakula-Juchnowicz
May 1, 2021·International Journal of Molecular Sciences·Anna LaitakariBirgitte Holst
Jul 17, 2021·Analytical and Bioanalytical Chemistry·Anntonette N PerryAshley E Ross
Aug 8, 2021·International Journal of Molecular Sciences·Yifan XuNabil J Alkayed
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Katarzyna SocałaPiotr Wlaź
Sep 30, 2021·Irish Journal of Medical Science·Xiaoqian WuZhichao Jiang

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