Zinc signaling in the hippocampus and its relation to pathogenesis of depression

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Atsushi Takeda

Abstract

Histochemically reactive zinc (Zn(2+)) is co-released with glutamate from zincergic neurons, a subclass of glutamatergic neurons. Zn(2+) serves as a signal factor in both the extracellular and intracellular compartments. Glucocorticoid-glutamatergic interactions have been proposed as a potential model to explain stress-mediated impairment of hippocampal function, i.e., cognition. However, it is unknown whether glucocorticoid-zincergic interactions are involved in this impairment. In the present study, involvement of synaptic Zn(2+) in stress-induced attenuation of CA1 LTP was examined in hippocampal slices from young rats after exposure to tail suspension stress for 30s, which significantly increased serum corticosterone. Stress-induced attenuation of CA1 LTP was ameliorated by administration of clioquinol, a membrane permeable zinc chelator, to rats prior to exposure to stress, implying that the reduction of synaptic Zn(2+) by clioquinol participates in this amelioration. To pursue the involvement of corticosterone-mediated Zn(2+) signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn(2+) was checked in hippocampal slices exposed to corticosterone. Corticosterone increased extracellular Zn(2+) levels measured with...Continue Reading

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Citations

Aug 27, 2013·Biological Trace Element Research·Liping TaoHui Shen
Jul 23, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Atsushi Takeda
Jul 31, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·E Padilla-GómezS Diaz-Cintra
Jan 13, 2015·Neuroscience Letters·Yuanyuan ZhengHui Shen
Feb 21, 2013·Metallomics : Integrated Biometal Science·Atsushi TakedaHaruna Tamano

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