Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats

Biological Trace Element Research
Susmita Barman, Krishnapura Srinivasan

Abstract

Non-enzymatic glycation of lens proteins and elevated polyol pathway in the eye lens have been the characteristic features of a diabetic condition. We have previously reported the benefits of zinc supplementation in reducing hyperglycemia and associated metabolic abnormalities and oxidative stress in diabetic rats. The current study explored whether zinc supplementation protects against cataractogenesis through modulation of glycation of lens proteins, elevated polyol pathway, oxidative stress, and proportion of different heat shock proteins in the eye lens of diabetic rats. Streptozotocin-induced diabetic rats were fed with a zinc-enriched diet (5 and 10 times of normal) for 6 weeks. Supplemental zinc alleviated the progression and maturation of diabetes-induced cataract. Zinc was also effective in preventing the reduced content of total and imbalanced proportion of soluble proteins in the lens. Supplemental zinc also alleviated cross-linked glycation and concomitant expression of the receptor of glycated products and oxidative stress indicators in the eye lens. Zinc supplementation further induced the concentration of heat shock protein in the eye lens of diabetic rats, specifically α-crystallin. Zinc supplementation countera...Continue Reading

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Citations

Apr 8, 2020·Oxidative Medicine and Cellular Longevity·Ricardo Raúl Robles-RiveraAdolfo Daniel Rodríguez-Carrizalez
Jul 6, 2018·International Journal of Environmental Research and Public Health·Adi PinkasMichael Aschner
Jan 23, 2020·Pharmaceuticals·Segewkal H HeruyeCatherine A Opere
Dec 16, 2020·Annual Review of Physical Chemistry·Marc A Sprague-PiercyRachel W Martin
May 4, 2021·Critical Reviews in Food Science and Nutrition·Susmita Barman, Krishnapura Srinivasan

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Methods Mentioned

BETA
Fluorescence
size exclusion chromatography
PCR

Software Mentioned

Graph
Pad
GeneTools
Prism

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