PMID: 11329502May 1, 2001Paper

Zinc supplementation does not attenuate alcohol-induced cerebellar Purkinje cell loss during the brain growth spurt period

Alcoholism, Clinical and Experimental Research
W J ChenJ R West

Abstract

Alcohol-induced zinc deficiency is one of the mechanisms proposed as a cause of developmental brain damage associated with fetal alcohol syndrome. It is known that alcohol exposure during the brain growth spurt period leads to cerebellar Purkinje cell loss. Therefore, this study examined whether zinc supplementation was capable of preventing alcohol-induced Purkinje cell loss in the cerebellar vermis in a neonatal rat model system. Sprague-Dawley rat pups were given alcohol (EtOH; 4.5 g/kg/day), zinc (Zn; 0.54 mg/ml diet; [10 times the regular diet Zn concentration]), or both from postnatal days (PD) 4 through 9 using the artificial-rearing paradigm. A gastrostomy control (GC) and a suckle control group (SC) also were included. All pups were killed on PD 10. Following perfusion, the cerebellar vermis was dissected and processed for stereological cell counting. The total number of Purkinje cells and the volume of the cerebellar vermis were determined. Alcohol produced a significant loss of Purkinje cells compared with that in the GC group (no EtOH and no Zn supplement). The zinc supplementation had no effect in attenuating alcohol-induced Purkinje cell loss in the cerebellar vermis. In fact, the serum zinc concentration data ind...Continue Reading

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Citations

Dec 3, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Raúl BallestínXavier Ponsoda
Jul 15, 2003·The Tohoku Journal of Experimental Medicine·Günfer TurgutOsman Genç
May 1, 2008·The International Journal of Neuroscience·A Cevik TufanEsat Adiguzel
Nov 17, 2005·The International Journal of Neuroscience·Mete KöksalHakan Kalender
Mar 11, 2008·Brain Research·Angeline M Antonio, Mary J Druse
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Jedidiah J Grisel, Wei-Jung A Chen
Jul 15, 2004·Alcoholism, Clinical and Experimental Research·Yuhua Z FarnellDavid J Earnest
Nov 28, 2017·European Journal of Nutrition·Anatoly V SkalnyAlexey A Tinkov
Nov 16, 2014·Advances in Nutrition·Jennifer K YoungMiyoung Suh

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