Abstract
Diabetic osteoporosis (DOP) is a complication of diabetes, with the characteristics of bone mineral density (BMD) reduction and bone structure destruction. Zinc was reported has a benefit effect on postmenopausal osteoporosise, it was also has hypoglycemic effect, whether zinc was beneficial on diabetes-induced osteoporosis has not been reported. So in the present study, we established a diabetic rat model by streptozotocin injection (60 mg/kg), and administered zinc sulfate by oral gavage to investigate the protective effects of zinc on DOP and the underline possible mechanism. Thirty six Sprague Dawley rats were divided into T1DM group (diabetic rats), control group (vehicle treatment), and T1DM-Zinc group (diabetic rats administered zinc sulfate 0.25 mg/kg by oral gavage). The bone histomorphological parameters, serum bone metabolism markers (including ALP, OPG, RUNX 2, and RANKL), BMD, and bone marrow adipocyte numbers were detected after eight weeks of zinc sulfate treatment. The results showed zinc sulfate administration (0.25 mg/kg/d) decreased blood glucose, increased the BMD, decreased serum ALP, and RANKL, increased serum OPG and RUNX 2 levels, as well as OPG/RANKL ratio of T1DM rats. Meanwhile, the bone histomorpholo...Continue Reading
References
Feb 15, 2000·Journal of Biomechanics·M StenströmG A Carlsson
Nov 16, 2001·Biogerontology·J JustesenM Kassem
Jan 14, 2003·Metabolism: Clinical and Experimental·Moon K SongVay Liang W Go
Mar 11, 2008·Molecular and Cellular Biochemistry·Masayoshi YamaguchiTaeko Nakagawa
Apr 9, 2008·Archives of Biochemistry and Biophysics·Brendan F Boyce, Lianping Xing
Aug 4, 2009·Cell and Tissue Research·Toshihisa Komori
Apr 30, 2009·Materials Science & Engineering. C, Materials for Biological Applications·Xia LiRacquel Z Legeros
Jan 18, 2012·Nature Reviews. Endocrinology·Christine HamannLorenz C Hofbauer
Jan 5, 2013·Nutrition Research Reviews·Fabrice Chimienti
Apr 11, 2013·Menopause : the Journal of the North American Menopause Society·Payal BhardwajMohan Lal Garg
May 11, 2013·Journal of Periodontology·Fawad JavedHoward C Tenenbaum
Jun 13, 2013·Journal of Cellular Biochemistry·Yu Zhang, Jian-Hong Yang
Aug 21, 2013·World Journal of Diabetes·Bipradas Roy
Jan 31, 2014·International Journal of Molecular Sciences·Ali AlkaladiMohamed Afifi
Feb 7, 2014·Archives of Physiology and Biochemistry·Abdulkerim Kasim BaltaciHatice Toy
Apr 18, 2014·Indian Journal of Endocrinology and Metabolism·Pooja Dhaon, Viral N Shah
Sep 23, 2014·Endocrinology·Guan-Wu LiXiao Shi
Nov 29, 2014·Biological Trace Element Research·Binbin LiShengnan Jia
Aug 6, 2015·The Journal of Clinical Endocrinology and Metabolism·Julien PaccouBernard Cortet
Aug 10, 2015·Current Osteoporosis Reports·Hongli JiaoDana T Graves
Sep 10, 2015·AAPS PharmSciTech·Ali Nazarizadeh, Siamak Asri-Rezaie
Oct 30, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Prisco PiscitelliAnnamaria Colao
Jul 28, 2016·Calcified Tissue International·Ann V Schwartz
Aug 7, 2016·Aging and Disease·Jiao LiLi Zhang
Mar 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Te WangXiaozhou Ying
Mar 25, 2017·BMC Complementary and Alternative Medicine·Jeong-Mi KimYoung-Rae Lee
Apr 15, 2017·Biological Trace Element Research·Hassan SadriSaeed Kolahian
May 16, 2017·European Journal of Pharmacology·Zu-Guo ZhengXiaojun Xu
Jun 21, 2017·Journal of Cellular Physiology·Adriana Lelis CarvalhoKatherine J Motyl
Aug 27, 2017·Biological Trace Element Research·Shanshan Qi
Oct 31, 2017·International Journal of Endocrinology·Cristina de Mello-SampayoM Cristina Marques
Jan 23, 2018·Histochemistry and Cell Biology·Toshihisa Komori
Feb 9, 2018·BMC Musculoskeletal Disorders·Ghaith A IshtayaWaleed M Sweileh
Apr 19, 2018·Food & Function·Fengjiao FanMing Du
Aug 2, 2018·BMC Research Notes·Mahmoud A AlfaqihSara Alqudah
Sep 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongxing ZhengChen Chen
May 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shanshan QiShiqiang Lan
Citations
May 16, 2020·Materials·J Patrick O'ConnorJessica A Cottrell
May 27, 2020·Biological Trace Element Research·Merve Nur CeylanNuray Yazihan
Jul 30, 2020·International Journal of Molecular Sciences·Hong Xing ZhengShan Shan Qi
Nov 6, 2020·Biological Trace Element Research·Azadeh Meshkini
Mar 20, 2021·Biological Trace Element Research·Yongjie XiongShaojun He
May 6, 2021·Life·Jin-Ho ParkJune-Ho Byun
May 3, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wei-Jie WangChien-Yu Lin
Jul 14, 2021·Annual Review of Nutrition·Inga WesselsLothar Rink