PMID: 8952028Nov 1, 1996Paper

Zinc toxicity with pancreatic acinar necrosis in piglets receiving total parenteral nutrition

Veterinary Pathology
K L GabrielsonD L Huso

Abstract

Two Hampshire-Duroc cross piglets maintained on 100% total parenteral nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.

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Citations

Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Liang GuoRobert J Cousins
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Kathryn C GambleThomas P Alvarado
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Michael M GarnerRobert W Nordhausen
Mar 7, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·R PieperA Bondzio
Jun 13, 2001·American Journal of Veterinary Research·G E MauldinF A Kallfelz
Jul 28, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tetsuya KomatsuTomoyuki Shibahara
Dec 30, 1998·The Journal of Nutrition·R L RemillardJ H Yardley

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